Fluconazole Impurity 18 CAS 383127-79-5
| CAS No. | 383127-79-5 |
| Molecular Formula | C10H12BrN |
| Molecular Weight | 226.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Fluconazole Impurity 18 (CAS 383127-79-5) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12BrN and a molecular weight of 226.11 g/mol.
Based on its molecular formula C10H12BrN, Fluconazole Impurity 18 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 226.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12BrN |
| Molecular Weight | 226.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Fluconazole Standards
- Fluconazole Impurity 28 (CAS CATO-C4X-101928)
- Fluconazole Impurity 29 (CAS CATO-C4X-101929)
- Fluconazole Impurity 40 (CAS 206050-23-9)
- Fluconazole EP Impurity E (CAS 86404-63-9)
- Fluconazole Impurity 41 (CAS CATO-C4X-101941)
- Fluconazole Impurity 46 (CAS 2013304-99-7)
- Fluconazole Impurity 12 (CAS 188416-33-3)
- Fluconazole EP Impurity G (R-Isomer) (CAS CATO-C4X-101965)
Recommended Standards
- n-[(4-bromophenyl)methyl]cyclopropanamine (CAS 70894-73-4)
- 3,4-Dichloro-6-fluoroquinoline (CAS 1204810-46-7)
- n-[(2-bromophenyl)methyl]cyclopropanamine (CAS 90868-91-0)
- 1-Ethyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (CAS 1233525-88-6)
- Ticagrelor Impurity 43 (CAS 145783-13-7)
- Abemaciclib Impurity 91 (CAS 937605-75-9)
- Dapagliflozin Impurity 138 (CAS CATO-C4X-1138138)
- Benzyl (4-methyl-1-((1-((3-morpholinopropyl)amino)-1,2-dioxopentan-3-yl)amino)-1-oxopentan-2-yl)carbamate (CAS 145731-49-3)
- 2-(Pyridin-3-yl)-4,5-dihydrothiazole-4-carboxylic acid (CAS 116247-03-1)
- (9,9-Diheptyl-9H-fluorene-2,7-diyl)diboronic acid (CAS 916336-19-1)
- 2-Bromo-7-chloro-9H-fluoren-9-one (CAS 96463-26-2)
- 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]ethan-1-ol (CAS 941867-93-2)
- 3-[(E)-[(2-Hydroxyphenyl)methylidene]amino]-2-phenyl-3,4-dihydroquinazolin-4-one (CAS 1392401-92-1)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
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