Tocopherol Impurity 41 CAS 389845-92-5
| CAS No. | 389845-92-5 |
| Molecular Formula | C87H144O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tocopherol Impurity 41.
As a process- or degradation-related impurity, Tocopherol Impurity 41 (CAS 389845-92-5, C87H144O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tocopherol Impurity 41 (C87H144O6) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 1286.10 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C87H144O6 |
| Molecular Weight | 1286.10 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Tocopherol Standards
- Tocopherol Impurity 26 (CAS 102340-61-4)
- α-Tocopherol glucoside (CAS 104832-72-6)
- (+)-Δ-Tocopherol (CAS 119-13-1)
- δ-Tocopherol Acetate (CAS 13027-26-4)
- Tocopherol (CAS 1406-66-2)
- (2S)-α-Tocopherol (Mixture of Diastereomers) (CAS 1411583-24-8)
- Alpha-Tocopherol-D6 Acetate (CAS 143731-16-2)
- alpha-Tocopherol quinol (CAS 14745-36-9)
Recommended Standards
- Halometasone impurity 12 (CAS CATO-C4X-144612)
- Clindamycin Impurity 20 (CAS 36688-78-5)
- Proguanil EP Impurity D Hydrochloride (CAS 35708-82-8)
- 4-(Difluoromethyl)-5,6-dimethoxypicolinaldehyde (CAS 1805325-32-9)
- 3-Isopropyl-1h-pyrazol-4-amine (CAS 1249021-45-1)
- 1-Bromo-3-(difluoromethoxy)-5-iodobenzene (CAS 1261775-70-5)
- Astressin (CAS 170809-51-5)
- 1-(4-(Aminomethyl)phenyl)-2-(4-methoxyphenyl)ethan-1-one (CAS 1017781-55-3)
- (3-Fluoro-4-(methoxy(methyl)carbamoyl)phenyl)boronic acid (CAS 913835-59-3)
- Cycloaspeptide D (CAS 691363-62-9)
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