Halometasone impurity 12 CAS CATO-C4X-144612
| CAS No. | CATO-C4X-144612 |
| Molecular Formula | C22H26Cl2F2O4 |
| Molecular Weight | 463.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Halometasone impurity 12 (CAS CATO-C4X-144612) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26Cl2F2O4 and a molecular weight of 463.34 g/mol.
The molecular framework of Halometasone impurity 12 (C22H26Cl2F2O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H26Cl2F2O4 |
| Molecular Weight | 463.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Halometasone Standards
- Halometasone impurity 10 (CAS CATO-C4X-144610)
- Halometasone impurity 13 (CAS CATO-C4X-144613)
- Halometasone Impurity 5 (CAS CATO-C4X-14465)
- Halometasone Impurity 8 (CAS 28895-70-7)
- Halometasone (CAS 50629-82-8)
- Halometasone Impurity 6 (CAS CATO-C4X-14466)
- Halometasone impurity 15 (CAS CATO-C4X-144615)
- Halometasone impurity 17 (CAS 35540-75-1)
Recommended Standards
- 2-Chloro-N-(2-chlorophenyl)-5-(2-(1-(pyridin-4-yl)ethylidene)hydrazine-1-carbonyl)benzenesulfonamide (CAS 731826-86-1)
- 3-(4-((4-Bromophenyl)sulfonyl)piperazin-1-yl)-6-(3-methyl-1H-pyrazol-1-yl)pyridazine (CAS 1013819-27-6)
- (2-{4-[2-(4-bromobenzoyl)cyclopropyl]phenyl}cyclopropyl)(4-fluorophenyl)methanone 1005270-52-9 KS-0000368Y (CAS 1005270-52-9)
- Chloro(crotyl)[di-tert-butyl(4-dimethylaminophenyl)phosphine]palladium(II) (CAS 1334497-06-1)
- Rebamipide impurity 22 (CAS 212502-72-2)
- Ursodeoxycholic Acid Impurity 113 (CAS CATO-C4X-1422113)
- Vortioxetine Impurity 114 (CAS 86632-33-9)
- Tetrahydrofuran-3-sulfonyl Chloride (CAS 1207346-29-9)
- 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]benzoic acid (CAS 1803566-59-7)
- 2-(Trifluoromethyl)benzyl thiocyanate (CAS 1233513-28-4)
- 3,7-Dimethylisoquinolin-1(2H)-one (CAS 1594089-67-4)
- 2-Amino-5-(4-chloro-5-methyl-1h-pyrazol-1-yl)-2-methylpentanamide (CAS 1342877-38-6)
- 1-(2-naphthyl)hexahydropyrimidine-2,4-dione (CAS 36797-69-0)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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