Citalopram Impurity 23 CAS 390817-87-5
| CAS No. | 390817-87-5 |
| Molecular Formula | C19H16F3N3O4 |
| Molecular Weight | 407.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Citalopram Impurity 23 (C19H16F3N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Citalopram Impurity 23 (CAS 390817-87-5, C19H16F3N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Citalopram Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H16F3N3O4 |
| Molecular Weight | 407.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Citalopram Standards
- Citalopram EP Impurity G (CAS 1329745-98-3)
- Citalopram Impurity 92 (CAS 1803244-58-7)
- Citalopram Impurity 95 (CAS CATO-C4X-110995)
- Citalopram Impurity 96 (CAS CATO-C4X-110996)
- Citalopram Impurity 54 (CAS CATO-C4X-110954)
- Citalopram Impurity 21 (CAS 1433278-32-0)
- Citalopram EP Impurity F (CAS 64169-39-7)
- Citalopram Impurity 83 (CAS CATO-C4X-110983)
Recommended Standards
- 3-(4-(2,4-Dichlorophenyl)thiazol-2-yl)-2-phenylthiazolidin-4-one (CAS 866048-97-7)
- 3-(4-Hydroxy-3-methoxyphenyl)-2-(2H-tetrazol-5-yl)-N-(3-(trifluoromethyl)phenyl)propanamide (CAS 483995-89-7)
- (E)-1-(3,4-dichlorobenzyl)-5,6-dimethyl-2-styryl-1H-benzo[d]imidazole (CAS 321433-05-0)
- 4-(1,3-Dithiolan-2-yl)phenyl 2,4-dichlorobenzenesulfonate (CAS 298218-19-6)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Troxipide Impurity 1 (CAS 31638-96-7)
- Moxifloxacin Impurity 158 (CAS CATO-C4X-1074158)
- 1,3-O-Isopropylidene (R)-Albuterol (2S,3S)-Di-O-toluoyl Tartrate Salt (CAS 238762-33-9)
- 3-Chloro-1-(4-methoxyphenyl)prop-2-en-1-one (CAS 15724-87-5)
- 2-Benzylchromeno[3,4-d]imidazol-4(3H)-one (CAS 638186-36-4)
- 2-Bromo-4-(4-(trifluoromethyl)phenyl)thiazole (CAS 886367-52-8)
- 3-ethyloxetane-3-carbaldehyde (CAS 98485-37-1)
- Methyl 2-methyl-2-(piperidin-4-yl)propanoate hydrochloride (CAS 861451-21-0)
- Peptide 434 (CAS CATO-CPTD788434)
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