Methyl 5-Fluorosalicylate CAS 391-92-4
| CAS No. | 391-92-4 |
| Molecular Formula | C8H7FO3 |
| Molecular Weight | 170.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 5-Fluorosalicylate.
Methyl 5-Fluorosalicylate (CAS 391-92-4) is a high-purity analytical reference standard with the molecular formula C8H7FO3 and a molecular weight of 170.14 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Methyl 5-Fluorosalicylate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 170.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7FO3 |
| Molecular Weight | 170.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Methyl Standards
Recommended Standards
- methyl 4-fluoro-3-hydroxybenzoate (CAS 214822-96-5)
- 5-Fluoro-2-methoxybenzoic acid (CAS 394-04-7)
- Methyl 4-Fluoro-2-hydroxybenzoate (CAS 392-04-1)
- 3-Fluoro-2-hydroxy-4-methyl-benzoic acid (CAS 1702914-15-5)
- 7-Fluorospiro[isochromane-1,4'-piperidine] (CAS 866029-25-6)
- 4,6-Dichloro-1-(methylamino)-2,3-dihydro-1h-inden-2-ol hydrochloride (CAS 1172327-40-0)
- 6-Fluoro-1-(2-fluoroethyl)-4-oxo-7-(pyridin-4-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (CAS 99108-92-6)
- 2,3,5-Trichloro-1,4-benzoquinone (CAS 634-85-5)
- Ibuprofen Impurity 86 (CAS CATO-C4X-108286)
- Ceftizoxime Impurity 10 (CAS 57028-71-4)
- 2-Bromo-5-((1-methylazetidin-3-yl)oxy)pyridine (CAS 1242156-74-6)
- Oxacyclohexadec-12-en-2-one, (12E)- (CAS 111879-80-2)
- Trimethyl(5-methylthiophen-2-yl)silane (CAS 18387-92-3)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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