Olmesartan Impurity 81 CAS 391052-99-5
| CAS No. | 391052-99-5 |
| Molecular Formula | C48H42N6O5 |
| Molecular Weight | 782.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Olmesartan Impurity 81 (CAS 391052-99-5) is a certified pharmaceutical impurity reference standard with the molecular formula C48H42N6O5 and a molecular weight of 782.88 g/mol.
Olmesartan Impurity 81 (C48H42N6O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C48H42N6O5 |
| Molecular Weight | 782.88 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 31.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 6 |
Related Olmesartan Standards
- Olmesartan Impurity 40 (CAS 1227626-51-8)
- Olmesartan Impurity 101 (CAS CATO-C4X-1097101)
- Olmesartan Impurity 100 (CAS CATO-C4X-1097100)
- Olmesartan Impurity 95 (CAS CATO-C4X-109795)
- Olmesartan Impurity 113 (CAS CATO-C4X-1097113)
- Olmesartan Impurity 112 (CAS 177965-02-5)
- Olmesartan Impurity 12 (CAS 144690-92-6)
- Olmesartan EP impurity D (CAS 1020157-01-0)
Recommended Standards
- Fulvestrant-17-Glucuronide (CAS 261506-28-9)
- Dehydro Olmesartan-2-trityl Medoxomil (CAS 1391052-99-5)
- Fulvestrant-3-Glucuronide (CAS 261506-27-8)
- Coblopasvir (CAS 1312608-46-0)
- Pregabalin Impurity 43 (CAS 1484267-23-3)
- Landiolol Impurity 61 (CAS CATO-C4X-262161)
- 3,4-Dimethyl-5-pentyl-2-furannonanoic Acid (CAS 57818-40-3)
- Azafenidin (CAS 68049-83-2)
- 1-Bromo-3-(difluoromethyl)-2-fluorobenzene (CAS 1204333-52-7)
- (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-mercaptobutanoate (CAS 630108-94-0)
- 5-Cyclopropoxy-6-fluoro-N-methylpyridin-3-amine (CAS 1243449-19-5)
- 1-(3-Bromo-benzyl)-4-ethoxy-1H-pyrazole (CAS 1869783-70-9)
- (R)-1-(4-(trifluoromethyl)phenyl)butan-1-amine (CAS 869318-96-7)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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