3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide CAS 391209-55-5
| CAS No. | 391209-55-5 |
| Molecular Formula | C15H12F3IN2O3 |
| Molecular Weight | 452.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide (CAS 391209-55-5) is a high-purity analytical reference standard with the molecular formula C15H12F3IN2O3 and a molecular weight of 452.17 g/mol.
The molecular framework of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide (C15H12F3IN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12F3IN2O3 |
| Molecular Weight | 452.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- Methyl 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-5-nitrobenzoate (CAS 836602-27-8)
- 1-(Difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1lambda3-benzo[d][1,2]iodaoxole (CAS 1052174-67-0)
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- 1-(5-(3,4-difluoro-2-(2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)ethoxy)phenyl)-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine (CAS 2059148-82-0)
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Recommended Standards
- 2-((2-Bromophenyl)(5-chloro-2-methoxyphenyl) methyl)-4-chloro-1-methoxybenzene (CAS 951771-27-0)
- (R)-3,3'-Dibromo-5,5',6,6',7,7',8,8'-octahydro-[1,1'-binaphthalene]-2,2'-diol (CAS 65355-08-0)
- 2-((3-Bromophenyl)(5-chloro-2-methoxyphenyl) methyl)-4-chloro-1-methoxybenzene (CAS 1011800-53-5)
- (S)-(-)-3,3'-Dibromo-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol (CAS 765278-73-7)
- Boc-(S)-3-Amino-4-(3-benzothienyl)-butyric acid (CAS 270063-45-1)
- 41828-04-0 N-[(E)-(3-Methoxy-2-propoxyphenyl)methylidene]hydroxylamine DTXSID80647295 (CAS 41828-04-0)
- 585566-43-4 1,5-Diphenyl-1,3,5-triazinane-2-thione MFCD03056978 (CAS 585566-43-4)
- 2,5-Dibromo-3-(difluoromethyl)pyridin-4-ol (CAS 1806838-73-2)
- 1-(1-Hydroxy-2-methylpropan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 444793-33-3)
- H-Lys-Lys-Lys-Trp-Lys-Lys-Lys-OH acetate salt (CAS 213836-45-4)
- (4-Amino-5-chloro-6-(difluoromethyl)pyridin-2-yl)methanol (CAS 1805061-28-2)
- 6-(5-Amino-2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (CAS 885230-03-5)
- tert-Butyl (1R,5S)-2-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 208037-77-8)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
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