4-(Trifluoromethyl)-1H-benzo[d]imidazole CAS 392-11-0
| CAS No. | 392-11-0 |
| Molecular Formula | C8H5F3N2 |
| Molecular Weight | 186.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-(Trifluoromethyl)-1H-benzo[d]imidazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-(Trifluoromethyl)-1H-benzo[d]imidazole (CAS 392-11-0) is a high-purity analytical reference standard with the molecular formula C8H5F3N2 and a molecular weight of 186.13 g/mol.
4-(Trifluoromethyl)-1H-benzo[d]imidazole (C8H5F3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5F3N2 |
| Molecular Weight | 186.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 4-(Trifluoromethyl)-1H-indazole (CAS 1000339-98-9)
- 2-(3-(Trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1000512-60-6)
- 2-(Trifluoromethyl)pyridine-3-acetonitrile (CAS 1000529-97-4)
- 2-(4-(Trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1000536-10-6)
- 2-(6-(Trifluoromethyl)pyridin-2-yl)acetonitrile (CAS 1000564-90-8)
- 3-(Trifluoromethyl)pyridine-5-acetonitrile (CAS 1000565-50-3)
- 4-(Trifluoromethyl)benzofuran (CAS 1065076-52-9)
- 4-(Trifluoromethyl)-7-azaindole (CAS 1092579-96-8)
Recommended Standards
- 3-Phenyl-3-(trifluoromethyl)diazirine (CAS 73899-14-6)
- 4,5,7-trifluoro-1-methyl-1H-1,3-benzodiazole (CAS 2688784-26-9)
- 3-Amino-5-(trifluoromethyl)benzonitrile (CAS 49674-28-4)
- 5-(Trifluoromethyl)-1H-indazole (CAS 885271-64-7)
- 2-(2-Cyclobutyl-4-methylthiazol-5-yl)acetic acid (CAS 1488791-28-1)
- 1-Cbz-azetidine-3-carboxylic Acid (CAS 97628-92-7)
- 4-(MEthylthio)-2-(trifluoromethyl)phenol (CAS 85092-98-4)
- 2-Amino-4-[(3-methyl-1-piperidyl)methyl]thiazole (CAS 855715-26-3)
- Dimethyl 2,2-Bis(hydroxymethyl)malonate (CAS 35329-73-8)
- 4-[(Tetrahydro-2-furanylmethyl)amino]-2-pyrimidinol (CAS 927803-70-1)
- 2,5-Bis(2,2,2-trifluoroethoxy)benzohydrazide (CAS 50778-75-1)
- (2-Methoxy-4-methylphenyl)methanamine (CAS 851670-22-9)
- 1-(1-Isopropyl-1H-pyrazol-4-yl)-N-((1-propyl-1H-pyrazol-5-yl)methyl)methanamine hydrochloride (CAS 1856080-29-9)
- endo-Gly31-Semaglutide (CAS CATO-C4X-2226282)
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