Ambroxol impurity 62 CAS 397323-70-5
| CAS No. | 397323-70-5 |
| Molecular Formula | C7H8BrNO |
| Molecular Weight | 202.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ambroxol impurity 62 (C7H8BrNO) is characterized by an amide group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ambroxol impurity 62 (CAS 397323-70-5) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8BrNO and a molecular weight of 202.05 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8BrNO |
| Molecular Weight | 202.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Ambroxol Standards
- Ambroxol Impurity 52 (CAS 946122-05-0)
- Ambroxol Impurity 19 (CAS 359867-42-8)
- Ambroxol Impurity 60 (CAS 59278-65-8)
- Ambroxol Impurity 84 (CAS CATO-C4X-108584)
- Ambroxol Impurity 16 (CAS 77820-58-7)
- Ambroxol Impurity N1 (CAS 46727-91-7)
- Ambroxol Impurity 44 (CAS 882772-99-8)
- Ambroxol impurity 61 (CAS 104670-74-8)
Recommended Standards
- 4-Bromo-3-methoxy-2-methylpyridine (CAS 1227592-47-3)
- (2-Amino-5-bromophenyl)methanol (CAS 20712-12-3)
- O-(4-bromobenzyl)hydroxylamine (CAS 55418-32-1)
- 2-(Hex-3-en-3-yl)benzo[d][1,3,2]dioxaborole (CAS 107648-56-6)
- Gadobutrol Impurity B HCl (CAS 2349341-85-9(free base))
- Procaterol Impurity 8 (CAS CATO-C4X-18108)
- Avibactam Impurity 56（2S,5R) (CAS 1192651-49-2)
- Ethyl 2-(6-chloro-5-fluoropyridin-3-yl)acetate (CAS 953780-50-2)
- Methyl 2-amino-3-(6-fluoro-1h-indol-3-yl)propanoate hydrochloride (CAS 1018815-57-0)
- 3-Isopropyl-1-propyl-5-vinyl-1H-pyrazole (CAS 1956328-24-7)
- Carbamic acid, N-[1-[[(2-methoxy-1-methylethyl)amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester (CAS 1323010-51-0)
- 1-[(4-methylphenyl)methyl]-1h-pyrazole-4-carboxylic acid (CAS 1006452-67-0)
- Cholecystokinin-33 (10-20) (bovine, porcine) (CAS 100900-23-0)
- Cycloaspeptide D (CAS 691363-62-9)
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