Fluticasone Impurity 21 CAS 397864-40-3
| CAS No. | 397864-40-3 |
| Molecular Formula | C26H28F2O6S |
| Molecular Weight | 506.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fluticasone Impurity 21 is closely related to a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Fluticasone Impurity 21 (CAS 397864-40-3) is a certified pharmaceutical impurity reference standard with the molecular formula C26H28F2O6S and a molecular weight of 506.56 g/mol.
Structurally, Fluticasone Impurity 21 (C26H28F2O6S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 506.56 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fluticasone Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H28F2O6S |
| Molecular Weight | 506.56 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Propionate-d5 (CAS 1093258-28-6)
- Fluticasone Impurity 82 (CAS CATO-C4X-165082)
- Fluticasone Impurity 59 (CAS CATO-C4X-165059)
- Fluticasone Impurity 66 (CAS 185536-05-4)
- 11-Oxo-fluticasone Furoate (CAS 397864-57-2)
- Fluticasone Impurity 69 (CAS CATO-C4X-165069)
- Fluticasone Propionate EP Impurity E (CAS 105613-90-9)
- Fluticasone Impurity 38 (CAS CATO-C4X-165038)
Recommended Standards
- BYS10-BP11 (CAS CATO-C3D-263163)
- Tepotinib impurity 7 (CAS 1103507-26-1)
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- Roblitinib (CAS 1708971-55-4)
- Perindopril Impurity 95 t-Butylamine (CAS CATO-C4X-125295)
- Amoxicillin Impurity 101 (CAS CATO-C4X-1148101)
- Vildagliptin Impurity 36 (CAS CATO-C4X-110036)
- Dicyclohexylamine ((2-nitrophenyl)thio)-L-valinate (CAS 7675-57-2)
- Methyl 3-(cyclohex-1-en-1-yl)-2-oxobutanoate (CAS 90107-26-9)
- Folic Acid Impurity 55 (CAS CATO-C4X-139555)
- 2-(2,4-Dimethoxyphenyl)-3-methylbutanoic acid (CAS 1226259-74-0)
- N-(2,4-dimethylphenyl)-2-(3-formylphenoxy)acetamide (CAS 706770-08-3)
- n-((1h-Imidazol-2-yl)methyl)-4-bromo-3-methoxyaniline (CAS 1384793-88-7)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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