Fluticasone Propionate EP Impurity E CAS 105613-90-9
| CAS No. | 105613-90-9 |
| Molecular Formula | C25H33F3O5S |
| Molecular Weight | 502.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fluticasone Propionate EP Impurity E.
Fluticasone Propionate EP Impurity E (CAS 105613-90-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33F3O5S and a molecular weight of 502.59 g/mol.
Structurally, Fluticasone Propionate EP Impurity E (C25H33F3O5S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 502.59 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H33F3O5S |
| Molecular Weight | 502.59 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Impurity 38 (CAS CATO-C4X-165038)
- Fluticasone Impurity 69 (CAS CATO-C4X-165069)
- Fluticasone Propionate EP Impurity J (CAS CATO-C4X-165019)
- Fluticasone Propionate (CAS 80474-14-2)
- Fluticasone Propionate-d5 (CAS 1093258-28-6)
- Fluticasone Impurity 21 (CAS 397864-40-3)
- Fluticasone Propionate EP Impurity F (CAS 1219174-94-3)
- Fluticasone Impurity 82 (CAS CATO-C4X-165082)
Recommended Standards
- Vardenafil Impurity 43 (CAS CATO-C4X-101743)
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- Vardenafil Impurity 40 (CAS CATO-C4X-101740)
- Conivaptan-d4 (CAS 1129433-63-1)
- Travoprost Impurity 38 Sodium Salt (CAS CATO-C4X-192538)
- Toremifene Impurity 11 (CAS CATO-C4X-139711)
- Orforglipron Impurity 41 (CAS CATO-C4X-323441)
- (1-Ethyl-3-nitro-1h-pyrazol-5-yl)methanol (CAS 1328640-72-7)
- Canagliflozin Impurity 10 (CAS 1818268-45-9)
- Dalbavancin B2 (CAS 871132-03-5)
- N-Phenylpyridin-3-amine (CAS 5024-68-0)
- 2-Bromo-5-(4-fluorobenzoyl)furan (CAS 500365-83-3)
- 7-Methoxy-2,6-naphthyridin-1(2H)-one (CAS 1393553-03-1)
- Neuropeptide S (human) (CAS 412938-67-1)
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