2-(4-Chloro-2-methylphenoxy)-N-(3,5-dimethoxyphenyl)-2,2-difluoroacetamide CAS 400087-84-5
| CAS No. | 400087-84-5 |
| Molecular Formula | C17H16ClF2NO4 |
| Molecular Weight | 371.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Chloro-2-methylphenoxy)-N-(3,5-dimethoxyphenyl)-2,2-difluoroacetamide (CAS 400087-84-5), molecular formula C17H16ClF2NO4 and molecular weight 371.76 g/mol, is a CATO reference standard with documented purity and traceability.
2-(4-Chloro-2-methylphenoxy)-N-(3,5-dimethoxyphenyl)-2,2-difluoroacetamide (C17H16ClF2NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-Chloro-2-methylphenoxy)-N-(3,5-dimethoxyphenyl)-2,2-difluoroacetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H16ClF2NO4 |
| Molecular Weight | 371.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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