Benidipine Impurity 46 CAS 40034-60-4
| CAS No. | 40034-60-4 |
| Molecular Formula | C13H12N2O2 |
| Molecular Weight | 228.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Benidipine Impurity 46 (CAS 40034-60-4) is a certified pharmaceutical impurity reference standard with the molecular formula C13H12N2O2 and a molecular weight of 228.25 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Benidipine Impurity 46 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 228.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H12N2O2 |
| Molecular Weight | 228.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 2 |
Related Benidipine Standards
- Benidipine Impurity 71 (CAS CATO-C4X-112071)
- Benidipine Impurity N1 (CAS 118431-03-1)
- Benidipine Impurity 11 (CAS 52604-00-9)
- Benidipine Impurity 13 (CAS 39562-17-9)
- Benidipine Impurity 17 (CAS 14813-01-5)
- Benidipine Impurity 12 (CAS 76509-17-6)
- Benidipine Impurity 33 (CAS 1536245-34-7)
- Benidipine Impurity 36 (CAS 864356-11-6)
Recommended Standards
- Ibrutinib Impurity 81 (CAS 143667-36-1)
- Sorafenib Impurity 10 (CAS 2004659-85-0)
- (2S)-2-amino-5-((5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)pentanoic acid (CAS 149204-50-2)
- Potassium Clavulanate impurity 22 (CAS 148601-26-7)
- WX390 Impurity 6 (CAS CATO-C4X-34316)
- Cyproheptadine impurity 14 (CAS 34663-46-2)
- Empagliflozin Impurity 293 (CAS 1185339-44-9)
- (3-Chloro-5-fluoro-2-hydroxyphenyl)(cyclopropyl)methanone (CAS 1251197-50-8)
- 1-(Sec-butyl)-1H-pyrazol-4-ol (CAS 75702-87-3)
- (E)-3-(P-tolyl)prop-2-en-1-amine (CAS 158223-55-3)
- 9-Chlorophenanthrene (CAS 947-72-8)
- 10-Isopropyl-3,10-diazabicyclo[4.3.1]decan-4-one (CAS 1209114-17-9)
- 2-Ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS 2098425-93-3)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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