(E)-3-(4-((2-chloro-6-fluorobenzyl)oxy)phenyl)acrylic acid CAS 400825-72-1
| CAS No. | 400825-72-1 |
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(4-((2-chloro-6-fluorobenzyl)oxy)phenyl)acrylic acid.
CATO supplies (E)-3-(4-((2-chloro-6-fluorobenzyl)oxy)phenyl)acrylic acid (CAS 400825-72-1), a certified reference material (molecular formula C16H12ClFO3, MW 306.72 g/mol) for analytical method development and quality control.
The molecular framework of (E)-3-(4-((2-chloro-6-fluorobenzyl)oxy)phenyl)acrylic acid (C16H12ClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (E)-3-(4-((2-chloro-6-fluorobenzyl)oxy)phenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related E Standards
- 2-Chloro-4-(1,3-dioxolan-2-yl)-4-fluorobenzophenone (CAS 898760-60-6)
- 3-{5-chloro-2-[(4-fluorophenyl)methoxy]phenyl}prop-2-enoic acid (CAS 938278-28-5)
- 3-Chloro-3-(1,3-dioxolan-2-yl)-4-fluorobenzophenone (CAS 898759-22-3)
- 3-Chloro-3-(1,3-dioxolan-2-yl)-5-fluorobenzophenone (CAS 898759-43-8)
- 4-((2-Chloro-5-nitrophenyl)sulfonyl)morpholine (CAS 40833-68-9)
- 4-(4-Chloro-3-nitro-benzenesulfonyl)-morpholine (CAS 22179-31-3)
- 4-Chloro-3-(1,3-dioxolan-2-yl)-2-fluorobenzophenone (CAS 898759-46-1)
- 898760-62-8 (3-Chloro-5-fluorophenyl)[4-(1,3-dioxolan-2-yl)phenyl]methanone DTXSID80645130 (CAS 898760-62-8)
Recommended Standards
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- (4-(1,3-Dioxolan-2-yl)phenyl)(4-chloro-3-fluorophenyl)methanone (CAS 898760-37-7)
- (4-(1,3-Dioxolan-2-yl)phenyl)(3-chloro-4-fluorophenyl)methanone (CAS 898760-40-2)
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