(4-(1,3-Dioxolan-2-yl)phenyl)(3-chloro-4-fluorophenyl)methanone CAS 898760-40-2
| CAS No. | 898760-40-2 |
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (4-(1,3-Dioxolan-2-yl)phenyl)(3-chloro-4-fluorophenyl)methanone (CAS 898760-40-2), a certified reference material (molecular formula C16H12ClFO3, MW 306.72 g/mol) for analytical method development and quality control.
(4-(1,3-Dioxolan-2-yl)phenyl)(3-chloro-4-fluorophenyl)methanone (C16H12ClFO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (4-(1,3-Dioxolan-2-yl)phenyl)(3-chloro-4-fluorophenyl)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12ClFO3 |
| Molecular Weight | 306.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Dioxolan Standards
- (3-(1,3-Dioxolan-2-yl)phenyl)(2-chloro-4-fluorophenyl)methanone (CAS 898759-40-5)
- (3-(1,3-Dioxolan-2-yl)phenyl)(4-chloro-3-fluorophenyl)methanone (CAS 898779-51-6)
- (4-(1,3-Dioxolan-2-yl)phenyl)(4-chloro-3-fluorophenyl)methanone (CAS 898760-37-7)
- 4-(2-Methyl-1,3-dioxolan-2-yl)pyridine (CAS 60553-33-5)
- 2-(3-((1,3-Dioxolan-2-yl)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 850411-08-4)
- 2-(4-((1,3-Dioxolan-2-yl)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 850411-10-8)
- 5-(1,3-Dioxolan-2-yl)-2-(3-nitrobenzoyl)thiophene (CAS 898778-31-9)
- 5-(1,3-Dioxolan-2-yl)-2-(4-Iodobenzoyl)thiophene (CAS 898778-16-0)
Recommended Standards
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- 1-(2-(5-Ethylthiophen-2-yl)-2-oxoethyl)-1h-1,2,4-triazole-3-carbonitrile (CAS 1240952-20-8)
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- 1-(4-Methylthiophen-2-yl)propan-1-one (CAS 106265-82-1)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
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