6-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline CAS 401567-88-2
| CAS No. | 401567-88-2 |
| Molecular Formula | C14H13ClF3N3 |
| Molecular Weight | 315.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline (CAS 401567-88-2), molecular formula C14H13ClF3N3 and molecular weight 315.72 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline (C14H13ClF3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H13ClF3N3 |
| Molecular Weight | 315.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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Recommended Standards
- 5-Chloro-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-indazol-1-yl)aniline (CAS 937606-23-0)
- 8-Chloro-4-(piperazin-1-yl)-2-(trifluoromethyl)quinoline (CAS 401567-90-6)
- 4-Chloro-2-(piperazin-1-yl)-6-(trifluoromethyl)quinoline (CAS 885270-52-0)
- Diethyl 2-(((3-chloro-4-fluorophenyl)amino)methylene)malonate (CAS 70032-30-3)
- rel-tert-Butyl (1R,2S,3R,5S)-3-amino-2-fluoro-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 2375918-49-1)
- (6-Chloro-4-methoxypyridin-2-yl)methanamine (CAS 1211519-72-0)
- Ethyl 2-(1-((benzyloxy)carbonyl)piperidin-4-yl)pyrimidine-5-carboxylate (CAS 1447607-85-3)
- 4-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)benzaldehyde (CAS 874782-05-5)
- 1-Bromo-2-butoxynaphthalene (CAS 169320-35-8)
- (4-Chlorocyclohexyl)benzene (CAS 394704-02-0)
- (1-Benzyl-1H-indol-2-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone (CAS 1022404-13-2)
- (Z)-3-Methylpenta-2,4-dienoic acid (CAS 30288-18-7)
- 2-(Hydroxymethyl)benzo[d]oxazole-6-acrylic acid (CAS 1803424-95-4)
- D-[Ala]24-Semaglutide (CAS CATO-C4X-2226126)
Why CATO?
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