2-(Methylsulfonyl)-5-(trifluoromethyl)aniline CAS 402-19-7
| CAS No. | 402-19-7 |
| Molecular Formula | C8H8F3NO2S |
| Molecular Weight | 239.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(Methylsulfonyl)-5-(trifluoromethyl)aniline (CAS 402-19-7), molecular formula C8H8F3NO2S and molecular weight 239.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Methylsulfonyl)-5-(trifluoromethyl)aniline (C8H8F3NO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H8F3NO2S |
| Molecular Weight | 239.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methylsulfonyl Standards
- 4-(Methylsulfonyl)-2-(trifluoromethyl)aniline (CAS 55080-84-7)
- 4-(Methylsulfonyl)-3-(trifluoromethyl)aniline (CAS 252561-92-5)
- 5-[4-(Methylsulfonyl)phenyl]-1,3,4-oxadiazol-2-amine (CAS 1016504-27-0)
- 5-[3-(Methylsulfonyl)phenyl]-1,3,4-oxadiazol-2-amine (CAS 1016764-70-7)
- 5-[2-(Methylsulfonyl)phenyl]-1,3,4-oxadiazol-2-amine (CAS 1105193-94-9)
- 4-(5-(Methylsulfonyl)-1,3,4-oxadiazol-2-yl)aniline (CAS 1858267-88-5)
- 2-(Methylsulfonyl)-1H-benzo[d]imidazole-4-carboxamide (CAS 636574-48-6)
- 2-Methyl-4-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 2803930-60-9)
Recommended Standards
- 2-(1,3-Dioxan-2-yl)-5-(trifluoromethyl)thiazole (CAS 2007909-08-0)
- 2,2,2-Trifluoroethyl (thiophen-2-ylmethyl)carbamate (CAS 923139-10-0)
- 1-Amino-2-(diethoxyphosphoryl)ethyl acetate (CAS 79428-78-7)
- 3-((4-Fluorophenyl)amino)pyrazine-2,5-dicarbonitrile (CAS 918410-44-3)
- 5-(4-Aminobenzyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (CAS 223429-84-3)
- (R)-6-bromo-7-chloro-2,3-dihydrobenzofuran-3-amine 1272731-95-9 QC-9319 (CAS 1272731-95-9)
- 5,7-Difluorobenzo[d]thiazol-2-amine (CAS 788124-34-5)
- 2-(3-(Benzyloxy)prop-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 862126-33-8)
- N-Boc-4-(methylamino)-1-(3-pyridyl)-1-butanone (CAS 1159977-15-7)
- 3-(3-Aminocyclohexyl)propanoic acid (CAS 90950-14-4)
- 4-[(2-Chlorobenzyl)oxy]benzoyl chloride (CAS 1160249-37-5)
- 2-(4-Hydroxytetrahydro-2H-pyran-4-yl)acetic acid (CAS 920297-23-0)
- 2-(chloromethyl)-3H,4H-thieno[2,3-d]pyrimidin-4-one (CAS 1039847-82-9)
- Tau Peptide (337-368) (Repeat 4 Domain) trifluoroacetate salt (CAS 330456-27-4)
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