N,N'-Bis[3-(trifluoromethyl)phenyl]propanediamide CAS 402-21-1
| CAS No. | 402-21-1 |
| Molecular Formula | C17H12F6N2O2 |
| Molecular Weight | 390.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
N,N'-Bis[3-(trifluoromethyl)phenyl]propanediamide (CAS 402-21-1), molecular formula C17H12F6N2O2 and molecular weight 390.28 g/mol, is a CATO reference standard with documented purity and traceability.
N,N'-Bis[3-(trifluoromethyl)phenyl]propanediamide (C17H12F6N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), N,N'-Bis[3-(trifluoromethyl)phenyl]propanediamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H12F6N2O2 |
| Molecular Weight | 390.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- cis-Permethrin Solution, 10 mg/L, 2 x 5 ml (CAS 54774-45-7)
- N1,N3-bis(2-(trifluoromethyl)phenyl)malonamide (CAS 339096-41-2)
- 3-(4-Bromophenyl)-5-phenyl-4-(p-tolyl)-4H-1,2,4-triazole (CAS 388079-95-6)
- N1,N3-bis(4-(trifluoromethyl)phenyl)malonamide (CAS 7574-50-7)
- 2-(4-Chlorothiophen-2-yl)acetaldehyde (CAS 1499659-20-9)
- cis-(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol-d4 (CAS 1217717-42-4)
- (2E)-2-{[(3-phenoxyphenyl)amino]methylidene}-2,3,4,9-tetrahydro-1H-carbazol-1-one (CAS 860612-40-4)
- 4-Ethylbenzofuran-2(3H)-one (CAS 742079-64-7)
- (2S,4aR,6S,7R,8R,8aR)-6-methoxy-2-(4-nitrophenyl)hexahydropyrano[3,2-d][1,3]dioxine-7,8-diol (CAS 849366-08-1)
- (3-Chloro-4-((3,4-dichlorobenzyl)oxy)-5-ethoxyphenyl)methanol (CAS 678158-52-6)
- N-(4-(Thiophen-2-yl)thiazol-2-yl)-2-(p-tolylthio)acetamide (CAS 851788-36-8)
- (2S)-2-Amino-1-(3-(methoxymethyl)pyrrolidin-1-yl)-3-methylbutan-1-one (CAS 1344971-29-4)
- 2-Amino-3-quinolinecarboxamide (CAS 31407-28-0)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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