Diphenhydramin EP Impurity B HCl (Dimenhydrinate EP Impurity G HCl) CAS 4024-34-4
| CAS No. | 4024-34-4 |
| Molecular Formula | C18H23NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Diphenhydramin EP Impurity B HCl (Dimenhydrinate EP Impurity G HCl) (C18H23NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Diphenhydramin EP Impurity B HCl (Dimenhydrinate EP Impurity G HCl) (CAS 4024-34-4), a pharmacopoeial impurity reference standard (molecular formula C18H23NOHCl, MW 305.85 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23NO HCl |
| Molecular Weight | 305.85 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Ilaprazole Impurity 220 (CAS CATO-C4X-1130220)
- Butylphthalide Impurity 66 (CAS 950681-46-6)
- Limaprost Impurity 14 (CAS CATO-C4X-214514)
- 3-Amino-2-(methylamino)benzoic acid (CAS 766491-67-2)
- Methyl 2-(1-ethyl-3-methyl-1h-pyrazol-4-yl)quinoline-4-carboxylate (CAS 1004644-10-3)
- (5-Cyclopropyl-1,3-oxazol-2-yl)methanamine (CAS 1216101-20-0)
- 6-Aminospiro[2.5]octane (CAS 99799-73-2)
- 3-Fluoro-6-iodopicolinonitrile (CAS 1803717-43-2)
- Drospirenone 5β-Hydroxy Impurity (CAS 197721-70-3)
- D-[Val]10-Semaglutide (CAS CATO-CPTD788630)
Why CATO?
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