(3,4-Difluorophenyl)methanamine hydrochloride CAS 403841-97-4
| CAS No. | 403841-97-4 |
| Molecular Formula | C7H7F2N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3,4-Difluorophenyl)methanamine hydrochloride is closely related to a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies (3,4-Difluorophenyl)methanamine hydrochloride (CAS 403841-97-4), a certified reference material (molecular formula C7H7F2NHCl, MW 179.59 g/mol) for analytical method development and quality control.
The molecular framework of (3,4-Difluorophenyl)methanamine hydrochloride (C7H7F2NHCl) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7F2N HCl |
| Molecular Weight | 179.59 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 1-(1-(2,6-Difluorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)ethanone (CAS 1000572-09-7)
- (2,4-Difluorophenyl)methanesulfonamide (CAS 1001026-56-7)
- Methyl 2-(2,3-difluorophenyl)-2-hydroxyacetate (CAS 1001159-03-0)
- 2-(2,4-Difluorophenyl)cyclopropan-1-amine (CAS 1001318-18-8)
- (4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonitrile (CAS 1002728-74-6)
- N-(2,5-Difluorophenyl)-3-methylbenzamide (CAS 1002813-62-8)
- 4-(3,5-Difluorophenyl)piperidinehydrochloride (CAS 1004618-89-6)
- 4-(2,3-difluorophenyl)piperidine hydrochloride (CAS 1004618-90-9)
Recommended Standards
- 2-(3-Hydroxy-5,5-dimethyloxolan-3-yl)acetic acid (CAS 1935538-27-4)
- N-Benzyl-4-[[4-(benzylamino)phenyl]methyl]aniline (CAS 51050-64-7)
- Dimethyl 5-(bromomethyl)-3-methyl-1h-pyrrole-2,4-dicarboxylate (CAS 786728-88-9)
- Amino Tadalafil (CAS 385769-84-6)
- (E)-{[1-(4-bromophenyl)-1H-pyrrol-3-yl]methylidene}amino acetate (CAS 860785-99-5)
- 3-(6-Chloro-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanenitrile (CAS 351003-20-8)
- 7-benzyl-1,3,7-triazaspiro[4.5]decane-2,4-dione (CAS 28937-10-2)
- Ethyl 6-chloro-4-((2-nitrobenzyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (CAS 866134-55-6)
- methyl 4-(1,5-dimethyl-1h-pyraZol-4-yl)-2,4-dioxobutanoate (CAS 1005585-96-5)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
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