3-Amino-5-chloropyrazine-2,6-dicarbonitrile CAS 40559-88-4
| CAS No. | 40559-88-4 |
| Molecular Formula | C6H2ClN5 |
| Molecular Weight | 179.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Amino-5-chloropyrazine-2,6-dicarbonitrile (CAS 40559-88-4), molecular formula C6H2ClN5 and molecular weight 179.57 g/mol, is a CATO reference standard with documented purity and traceability.
3-Amino-5-chloropyrazine-2,6-dicarbonitrile (C6H2ClN5) contains a nitrile group, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H2ClN5 |
| Molecular Weight | 179.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Amino Standards
- 5-Amino-6-chloro-2,3-dicyanopyrazine (CAS 56413-96-8)
- 5-amino-2-chloro-pyrimidine-4-carboxylic acid (CAS 1052714-41-6)
- 3-amino-5-chloro-pyrazine-2-carboxylic acid (CAS 1260663-68-0)
- 2-Amino-8-chloroquinazoline (CAS 1185113-73-8)
- 4-Amino-6-chlorocinnoline (CAS 18259-66-0)
- 2-Amino-5-chloroquinazoline (CAS 190273-70-2)
- 2-Amino-7-chloroquinazoline (CAS 190274-08-9)
- 2-Amino-6-chloroquinazoline (CAS 20028-71-1)
Recommended Standards
- 2H-Pyrazolo[4,3-d]pyrimidine-3-carbonitrile, 5-chloro- (CAS 2092193-29-6)
- 5-Chloro-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile (CAS 1260671-41-7)
- 4-Chloro-5-nitrothiazol-2-amine (CAS 127507-89-5)
- 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile (CAS 1004991-91-6)
- 4-Nitrophenyl benzoate (CAS 959-22-8)
- 3-ethynyl-5-fluoropyridine (CAS 872122-54-8)
- Pentafluoroanilinium Trifluoromethanesulfonate (CAS 912823-79-1)
- 2-Chloro-3-fluoro-5-iodopyridin-4-amine (CAS 1801841-62-2)
- 3-Phenoxy-5-(trifluoromethyl)picolinamide (CAS 1065607-72-8)
- tert-Butyl (5-iodothiazol-4-yl)carbamate (CAS 1258934-68-7)
- 4-(5-Chloro-2-thienyl)-4-oxobutyric Acid (CAS 70685-06-2)
- 4-(2-bromoethynyl)-1-methyl-pyrazole (CAS 2737342-90-2)
- 6-Ethyl-N-(3-morpholinopropyl)benzo[d]thiazol-2-amine (CAS 1204298-12-3)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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