(1S,3S)-Tryptophan EP Impurity I CAS 40678-46-4
| CAS No. | 40678-46-4 |
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1S,3S)-Tryptophan EP Impurity I.
As a process- or degradation-related impurity, (1S,3S)-Tryptophan EP Impurity I (CAS 40678-46-4, C13H14N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
(1S,3S)-Tryptophan EP Impurity I (C13H14N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), (1S,3S)-Tryptophan EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 2 |
Recommended Standards
- (1R,6S)-6-benzoylcyclohex-3-ene-1-carboxylic acid (CAS 35033-78-4)
- (2E)-3-(Dimethylamino)-2-(4-methoxybenzoyl)acrylonitrile (CAS 96219-74-8)
- (1R,3S)-Tryptophan EP Impurity I (CAS 42438-72-2)
- (2-Hydroxy-5-isopropylphenyl)(1H-pyrazol-4-yl)methanone (CAS 288844-41-7)
- Travoprost Impurity 21 (CAS CATO-C4X-192521)
- Indobufen Impurity 25 (CAS CATO-C4X-179225)
- Linezolid Impurity 63 (CAS 348626-43-7)
- 5,5-Difluoro-1-methyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid (CAS 1784893-60-2)
- 1H-Pyrrole-2,5-dione, 1,1'-(methylenedi-4,1-phenylene)bis-, polymer with 2,4-bis[(4-aminophenyl)methyl]benzenamine and 4,4'-methylenebis[benzenamine] (CAS 102900-05-0)
- N-[4-(dimethylamino)butan-2-yl]oxetan-3-amine (CAS 1340390-43-3)
- (S)-4-(1-Aminoethyl)-3-(trifluoromethyl)benzonitrile (CAS 1388123-31-6)
- 6-Benzyl-3-isobutylpyrazin-2(1H)-one (CAS 169195-23-7)
- 6-Bromo-3-cyano-2-(difluoromethyl)benzoic acid (CAS 1805581-20-7)
- Nonapeptide-1 (CAS 158563-45-2)
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