Promethazine Impurity 72 CAS 409314-72-3
| CAS No. | 409314-72-3 |
| Molecular Formula | C4H10ClN |
| Molecular Weight | 107.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Promethazine Impurity 72.
As a process- or degradation-related impurity, Promethazine Impurity 72 (CAS 409314-72-3, C4H10ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Promethazine Impurity 72 (C4H10ClN) contains chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Promethazine Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H10ClN |
| Molecular Weight | 107.58 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Promethazine Standards
- Promethazine Impurity 24 (CAS 1070758-14-3)
- Promethazine Impurity 11 (CAS 108-16-7)
- Promethazine Impurity 26 (CAS 15521-18-3)
- Promethazine Impurity 23 (CAS 64505-48-2)
- Promethazine Impurity 69 (CAS 129286-73-3)
- Promethazine Impurity 57 (CAS 75411-83-5)
- Promethazine Impurity 68 (CAS 121861-55-0)
- Promethazine Impurity 22 (CAS 37143-56-9)
Recommended Standards
- Chloromethyl(dimethyl)silane (CAS 3144-74-9)
- Chlorpromazine Impurity 9 (CAS 65232-62-4)
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- 4-Chlorobutan-1-amine (CAS 42330-95-0)
- Roxatidine Impurity 60 (CAS CATO-C4X-121360)
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- 3-Chloro-2,2-dimethyl-N-(thiazol-2-yl)propanamide (CAS 454473-70-2)
- AROCLOR 5442(Mixture of isomers) (CAS 12642-23-8)
- 1-(Pyridin-4-yl)-1H-imidazole-4-carboxylic acid (CAS 1339544-04-5)
- (E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide (CAS 1550008-55-3)
- 3-(3-Chloro-1H-1,2,4-triazol-1-yl)propanenitrile (CAS 1351698-84-4)
- 5-Amino-3-methylisoxazole (CAS 14678-02-5)
- Insulin Pork(≥27 USP units/mg) (CAS 12584-58-6)
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