Salbutamol Impurity 80 CAS 41104-10-3
| CAS No. | 41104-10-3 |
| Molecular Formula | C10H9BrO3 |
| Molecular Weight | 257.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Salbutamol Impurity 80 (CAS 41104-10-3, C10H9BrO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Salbutamol Impurity 80 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 257.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9BrO3 |
| Molecular Weight | 257.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Br-containing |
Related Salbutamol Standards
- Salbutamol Impurity 122 (CAS CATO-C4X-1176122)
- Salbutamol Impurity 113 (CAS CATO-C4X-1176113)
- Salbutamol Impurity 70 (CAS CATO-C4X-117670)
- Salbutamol Impurity 147 (CAS 62423-71-6)
- Salbutamol Impurity 129 (CAS 18910-69-5)
- Salbutamol EP Impurity M (CAS 18910-70-8)
- Salbutamol EP Impurity A(R-Isomer) (CAS CATO-C4X-1176198)
- Salbutamol EP Impurity M(R-Isomer) (CAS CATO-C4X-1176201)
Recommended Standards
- Lamotrigine EP Impurity A (CAS 252186-78-0)
- 898765-21-4 4-(2-Bromophenyl)-4-oxobutanoic acid DTXSID00645278 (CAS 898765-21-4)
- Cenobamate Impurity 27 (CAS 1452161-91-9)
- N-Cyclopropyl 4-bromo-2-nitroaniline (CAS 887351-39-5)
- Norethisterone EP Impurity G (CAS 38673-36-8)
- Dotinurad Impurity 65 (CAS 38925-98-3)
- Eplerenone Impurity N1 (CAS 209253-72-5)
- 2-(Dicyclohexylamino)ethanol (CAS 4500-31-6)
- Naphthalen-1-yl furan-2-carboxylate (CAS 354796-43-3)
- 3,6-Difluoropicolinaldehyde (CAS 1227583-74-5)
- 2-(4-(Diethylamino)phenyl)-6-methyl-2H-benzo[d][1,2,3]triazol-5-amine (CAS 381208-40-8)
- 4-Bromo-3,5-dihydroxybenzoic Acid (CAS 16534-12-6)
- 5-(2,4-Dichlorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 29527-30-8)
- Semaglutide Impurity 176 (CAS CATO-C4X-2226176)
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