Cenobamate Impurity 27 CAS 1452161-91-9
| CAS No. | 1452161-91-9 |
| Molecular Formula | C9H6Cl2N4O |
| Molecular Weight | 257.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cenobamate Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Cenobamate Impurity 27 (CAS 1452161-91-9) is a certified pharmaceutical impurity reference standard with the molecular formula C9H6Cl2N4O and a molecular weight of 257.08 g/mol.
The molecular framework of Cenobamate Impurity 27 (C9H6Cl2N4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H6Cl2N4O |
| Molecular Weight | 257.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Cenobamate Standards
- Cenobamate Impurity 28 (CAS 220902-32-9)
- Cenobamate Impurity 25 (CAS CATO-C4X-241625)
- Cenobamate Impurity 53 (CAS CATO-C4X-241653)
- Cenobamate Impurity 59 (CAS CATO-C4X-241659)
- Cenobamate Impurity 54 (CAS 1233712-93-0)
- Cenobamate Impurity 15 (CAS CATO-C4X-241615)
- Cenobamate impurity 01 (CAS 913089-08-4)
- Cenobamate S isomer (CAS CATO-C4X-24161)
Recommended Standards
- Lamotrigine EP Impurity A (CAS 252186-78-0)
- Salbutamol Impurity 80 (CAS 41104-10-3)
- Alpha-bromo-3'-acetoxyacetophenone (CAS 38396-89-3)
- Salbutamol Impurity 122 (CAS CATO-C4X-1176122)
- Flurbiprofen Impurity 140 (CAS 1531637-33-8)
- Formoterol Impurity 25 (CAS CATO-C4X-152525)
- Calcitriol Impurity 36 (CAS 66774-84-3)
- 4-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride (CAS 129768-26-9)
- 4-(4-(4-Bromophenyl)-5-((naphthalen-1-ylmethyl)thio)-4H-1,2,4-triazol-3-yl)pyridine (CAS 676643-89-3)
- Samarium(III) nitrate hexahydrate (CAS 13759-83-6)
- Methoxydiphenylborane (CAS 13471-36-8)
- 4-Bromo-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl (CAS 101532-36-9)
- Lumateperone impurity 57 (CAS CATO-C4X-220157)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
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