5-(4-Hydroxyphenyl)-2-hydroxypyridine CAS 41216-12-0
| CAS No. | 41216-12-0 |
| Molecular Formula | C11H9NO2 |
| Molecular Weight | 187.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(4-Hydroxyphenyl)-2-hydroxypyridine (CAS 41216-12-0), molecular formula C11H9NO2 and molecular weight 187.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(4-Hydroxyphenyl)-2-hydroxypyridine (C11H9NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(4-Hydroxyphenyl)-2-hydroxypyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9NO2 |
| Molecular Weight | 187.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 1 |
Related Hydroxyphenyl Standards
- 5-(2-Hydroxyphenyl)pyridin-2-ol (CAS 1111102-89-6)
- 6-(4-Hydroxyphenyl)-2-hydroxypyridine (CAS 1111114-77-2)
- 1-(3-hydroxyphenyl)-1,2-dihydropyridin-2-one (CAS 3534-60-9)
- 1-(4-Hydroxyphenyl)-1h-pyrrole-2-carbaldehyde (CAS 444077-56-9)
- 1-(4-Hydroxyphenyl)pyridin-2(1H)-one (CAS 859538-51-5)
- N-(2-Hydroxyphenyl)methanesulfonamide (CAS 6912-38-5)
- N-(3-hydroxyphenyl)methanesulfonamide (CAS 71290-40-9)
- 81201-90-3 L-4-Hydroxyphenyl-4-13C-alanine L-Tyrosine-(phenyl-4-13C) (CAS 81201-90-3)
Recommended Standards
- 5-(4-Ethynylphenyl)oxazolidin-2-one (CAS 2228264-44-4)
- 5-(Methoxycarbonyl)piperidine-3-carboxylic acid (CAS 748113-39-5)
- 5-(4-Aminophenyl)furan-2-carbaldehyde (CAS 57023-90-2)
- 5-(P-tolyl)isoxazole-3-carbaldehyde (CAS 640292-02-0)
- Methyl 2-oxo-1,2-dihydropyrimidine-4-carboxylate (CAS 950514-14-4)
- 7-(5-Bromo-2-fluorophenyl)-5,8-diazaspiro[3.4]octan-6-one (CAS 1272755-91-5)
- 1-Methyl-1H-imidazole-2-carboxylic acid (CAS 20485-43-2)
- Pregabalin Impurity 136 (CAS CATO-C4X-1312136)
- 4-((4-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)piperidin-1-yl)methyl)-2-phenylthiazole (CAS 1396866-04-8)
- 5-Boc-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (CAS 1434052-06-8)
- 4-Oxo-2-trifluoromethyl-tetrahydro-thiophene-3-carboxylic acid methyl ester (CAS 51907-02-9)
- 2-Fluoro-7-azaspiro[3.5]nonane (CAS 1263178-15-9)
- 4-Bromo-2,3-difluorobenzaldehyde (CAS 644985-24-0)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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