Topiramate Impurity 14 CAS 4136-95-2
| CAS No. | 4136-95-2 |
| Molecular Formula | C7H2Cl4O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Topiramate Impurity 14 (CAS 4136-95-2) is a certified pharmaceutical impurity reference standard with the molecular formula C7H2Cl4O and a molecular weight of 243.89 g/mol.
The molecular framework of Topiramate Impurity 14 (C7H2Cl4O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Topiramate Impurity 14 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H2Cl4O |
| Molecular Weight | 243.89 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Topiramate Standards
- Topiramate Azidosulfate (CAS 106881-35-0)
- Topiramate EP Impurity C (CAS 106881-41-8)
- Topiramate Didesacetal Impurity (CAS 106881-42-9)
- Topiramate Didesacetal Impurity Formate (CAS 106881-42-9（free base）)
- Topiramate Impurity 27 (CAS 120238-48-4)
- Topiramate-<SUP>13</SUP>C<SUB>6</SUB> (CAS 1217455-55-4)
- Topiramate-d12 (CAS 1279037-95-4)
- Topiramate Impurity 15 (CAS 128316-82-5)
Recommended Standards
- Iguratimod Impurity 63 (CAS CATO-C4X-182663)
- Ursodeoxycholic Acid impurity 76 (CAS CATO-C4X-142276)
- Levocarnitine Impurity 40 (CAS CATO-C4X-129240)
- <SC>L </SC>-Oxidized glutathione disodium salt (CAS 103239-24-3)
- 1-(4-Methyl-6-(methylthio)pyridin-3-yl)propan-1-one (CAS 1355177-73-9)
- 4-Chloro-3-(methylsulfonyl)benzamide (CAS 848053-72-5)
- 6-Chloro-2-ethoxy-3-nitropyridine (CAS 1094323-19-9)
- 1-{[2-(4-tert-butylphenoxy)-1,3-thiazol-5-yl]methyl}-4-phenylpiperazine (CAS 439097-07-1)
- 6'-Methoxy-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione (CAS 66892-37-3)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com