(4-Chlorophenyl)(thiophen-2-yl)methanone CAS 4153-45-1
| CAS No. | 4153-45-1 |
| Molecular Formula | C11H7ClOS |
| Molecular Weight | 222.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(4-Chlorophenyl)(thiophen-2-yl)methanone (CAS 4153-45-1), molecular formula C11H7ClOS and molecular weight 222.69 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (4-Chlorophenyl)(thiophen-2-yl)methanone (C11H7ClOS) is characterized by sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), (4-Chlorophenyl)(thiophen-2-yl)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7ClOS |
| Molecular Weight | 222.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
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- 6-(3-Chlorophenyl)pyridazine-3(2H)-thione (CAS 1239741-45-7)
- 4-(4-Chlorophenyl)-2-mercaptopyrimidine (CAS 175203-08-4)
- (3-Chlorophenyl)(thiophen-3-yl)methanone (CAS 896618-55-6)
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Recommended Standards
- (5-Chlorothiophen-2-yl)(phenyl)methanone (CAS 56824-84-1)
- 4-chlorothieno[2,3-d]pyrimidine-2-carboxylic acid (CAS 1934817-82-9)
- 2-Chloro-4-(phenylsulfanyl)pyrimidine (CAS 191729-21-2)
- 2-((5-Chloro-1H-indol-3-yl)thio)acetonitrile (CAS 61021-33-8)
- Cycloheptyl(2,4-difluorophenyl)methanone (CAS 1443328-85-5)
- 6-Bromo-2-(2-methoxyethyl)isoindolin-1-one (CAS 1344692-89-2)
- Ethyl 2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetate (CAS 338979-08-1)
- 3-(dihydroxyboranyl)propanoic acid (CAS 220999-41-7)
- Rimegepant Impurity 95 (CAS CATO-C4X-248795)
- 2-Amino-5-bromo-4-chlorobenzoic acid hydrochloride (CAS 1820705-17-6)
- Carrier Protein 3 (CAS CATO-CPTD788445)
- 2-Butyl-3-ethoxy-N-(furan-2-ylmethyl)-2H-indazole-6-carboxamide (CAS 919107-20-3)
- 3-amino-2-(2-furylmethyl)propan-1-ol (CAS 949226-57-7)
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
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