4,6-Dihydroxy-1H-indole-2-carboxylic acid CAS 420137-13-9
| CAS No. | 420137-13-9 |
| Molecular Formula | C9H7NO4 |
| Molecular Weight | 193.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4,6-Dihydroxy-1H-indole-2-carboxylic acid (C9H7NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4,6-Dihydroxy-1H-indole-2-carboxylic acid (CAS 420137-13-9), molecular formula C9H7NO4 and molecular weight 193.16 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,6-Dihydroxy-1H-indole-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7NO4 |
| Molecular Weight | 193.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Dihydroxy Standards
- 5,6-Dihydroxy-1-methyl-1H-indole-2,3-dione (CAS 121404-58-8)
- (S)-5,7-Dihydroxy-2-methyl-2,3-dihydroquinolin-4(1H)-one (CAS 65511-03-7)
- 2-(4,5-Dihydroxy-2-nitrophenyl)acetonitrile (CAS 117568-28-2)
- 6,8-Dihydroxy-3-methylisocoumarin (CAS 1204-37-1)
- 3,6-dihydroxy-2-methyl-3,4-dihydroquinazolin-4-one (CAS 1322604-74-9)
- 6,7-Dihydroxy-3-methyl-2H-chromen-2-one (CAS 16574-10-0)
- 2,3-Dihydroxy-2,3-dihydronaphthalene-1,4-dione (CAS 34785-82-5)
- 4,5-Dihydroxy-6-methyl-2H-chromen-2-one (CAS 876720-70-6)
Recommended Standards
- 4-(2-Nitrovinyl)benzoic acid (CAS 3179-11-1)
- 4-[(carbamoylimino)amino]benzoic acid (CAS 41779-98-0)
- 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid (CAS 24132-22-7)
- 4-Acetyl-2-nitrobenzaldehyde (CAS 933443-35-7)
- Ethyl (S)-2-(1H-pyrrol-1-yl)propanoate (CAS 935765-03-0)
- 5-[2-Chloro-4-(Trifluoromethyl)Phenoxy]-2-Nitrophenol (CAS 42874-63-5)
- 2-(hydroxymethyl)-2-(pyridin-4-yl)propane-1,3-diol (CAS 20845-48-1)
- 5-Bromo-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde (CAS 1367950-88-6)
- Ramelteon Impurity 34 (CAS 1356395-13-5)
- 3-Acetoxy-2,4-dimethylbenzophenone (CAS 890099-08-8)
- Dimethyl 5-(4-chlorophenyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate 2-oxide (CAS 339102-15-7)
- Fluorometholone Impurity 6 (CAS 110664-58-9)
- 1-(2-(1H-Imidazo[1,2-b]pyrazol-1-yl)ethyl)-3-(3,4-dimethylphenyl)urea (CAS 1795298-13-3)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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