2-(6-(Azepan-1-yl)-2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-N-hydroxyacetamide CAS 42055-79-8
| CAS No. | 42055-79-8 |
| Molecular Formula | C19H21F3N4O2 |
| Molecular Weight | 394.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 394.39 g/mol gives 2-(6-(Azepan-1-yl)-2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-N-hydroxyacetamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(6-(Azepan-1-yl)-2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-N-hydroxyacetamide (CAS 42055-79-8) is a high-purity analytical reference standard with the molecular formula C19H21F3N4O2 and a molecular weight of 394.39 g/mol.
The molecular framework of 2-(6-(Azepan-1-yl)-2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-N-hydroxyacetamide (C19H21F3N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(6-(Azepan-1-yl)-2-(3-(trifluoromethyl)phenyl)pyrimidin-4-yl)-N-hydroxyacetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H21F3N4O2 |
| Molecular Weight | 394.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Azepan Standards
- 3-(Azepan-1-ylsulfonyl)-4-chloro-N-(pyridin-3-yl)benzamide (CAS 377763-51-4)
- 1-(Azepan-1-yl)-2-(4-(4-(thiophen-2-yl)pyrimidin-2-yl)phenoxy)ethan-1-one (CAS 477889-43-3)
- 2-((2-(Azepan-1-yl)-6-methylpyrimidin-4-yl)oxy)-N-(2-chloro-4-fluorophenyl)acetamide (CAS 1226434-87-2)
- 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-n-(4-methylphenyl)-1-benzofuran-3-carboxamide (CAS 880440-91-5)
- 5-(2-(Azepan-1-yl)-2-oxoethoxy)-2-benzyl-3,4-dihydroisoquinolin-1(2H)-one (CAS 850905-42-9)
- 1-(Azepan-1-yl)-2-(3-(phenylsulfonyl)-1H-indol-1-yl)ethan-1-one (CAS 941925-03-7)
- 4-((2-(Azepan-1-ylsulfonyl)ethyl)(pyridin-4-ylmethyl)amino)-4-oxobutanoic acid (CAS 919748-82-6)
- N-(2-(azepan-1-yl)-5-chlorophenyl)-2,4-dichlorobenzamide (CAS 383146-68-7)
Recommended Standards
- N-(2-Ethoxyphenyl)-2-(4-(trifluoromethyl)phenyl)morpholine-4-carboxamide (CAS 1351619-69-6)
- 2-{[2-(trifluoromethyl)phenyl]carbamoyl}thiophen-3-yl N,N-dimethylsulfamate (CAS 338794-22-2)
- 1311284-02-2 N'-[1-[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)Ph]-meth-(E)-ylidene]-N-Me-hydrazinecarboxylic acid ethyl ester MFCD19981268 (CAS 1311284-02-2)
- 2-{[3-(trifluoromethyl)phenyl]carbamoyl}thiophen-3-yl N,N-dimethylsulfamate (CAS 338794-15-3)
- (2E)-2-[(E)-1-Methyl-1H-pyrrole-2-carbonyl]-3-(thiophen-3-yl)prop-2-enenitrile (CAS 900019-56-9)
- Oxohygrolidin (CAS 98813-11-7)
- 2-(6-Chloronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 870822-85-8)
- Benzyl ((2S,4s,5S)-5-aminospiro[3.3]Heptan-2-yl)carbamate (CAS 1682749-20-7)
- 2'-Chloro-5'-methoxy-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261974-52-0)
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- Leflunomide (CAS 75706-12-6)
- 4-Methyl-3-(methylthio)-1H-1,2,4-triazol-5(4H)-one (CAS 53065-38-6)
- 4-Allyl-5-(quinolin-6-yl)-4H-1,2,4-triazole-3-thiol (CAS 306935-48-8)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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