Edoxaban Impurity 104 CAS 4214-74-8
| CAS No. | 4214-74-8 |
| Molecular Formula | C5H4Cl2N2 |
| Molecular Weight | 163.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Edoxaban Impurity 104 (CAS 4214-74-8), a pharmacopoeial impurity reference standard (molecular formula C5H4Cl2N2, MW 163.00 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Edoxaban Impurity 104 (C5H4Cl2N2) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C5H4Cl2N2 |
| Molecular Weight | 163.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Edoxaban Standards
- Edoxaban Impurity 108 (CAS CATO-C4X-1063108)
- Edoxaban Impurity 111 (CAS CATO-C4X-1063111)
- Edoxaban Impurity 68 (CAS 17899-48-8)
- Edoxaban Impurity 87 (CAS 97164-95-9)
- Edoxaban Impurity 31 (CAS 259809-24-0)
- Edoxaban Impurity 110 (CAS CATO-C4X-1063110)
- Edoxaban Impurity N82 (CAS 165948-23-2)
- Edoxaban Impurity 103 (CAS 929693-36-7)
Recommended Standards
- 2,3-Dichloropyridin-4-amine (CAS 184416-83-9)
- Roflumilast USP Related Compound C (CAS 22889-78-7)
- 2,5-Dichloropyridin-4-amine (CAS 405230-82-2)
- Dasatinib Impurity 42 (CAS 1780-26-3)
- Clindamycin Impurity 85 (CAS CATO-C4X-134185)
- Eravacycline impurity 40 (CAS CATO-C4X-293840)
- Gemfibrozil EP Impurity H (CAS 415724-02-6)
- 2-(4-Chlorobenzoyl)-4-methylmorpholine (CAS 1427379-80-3)
- 3-(4-Aminophenyl)-4,5-dihydro-1,2,4-oxadiazol-5-one hydrochloride (CAS 1341040-36-5)
- N-Allyl-5-bromo-2-pyridinamine (CAS 106037-57-4)
- 3-Bromo-4-(morpholinomethyl)aniline (CAS 5200-66-8)
- 2-Chloro-N-[4-(1-cyanocyclopentyl)phenyl]-3-pyridinecarboxamide (CAS 1158560-99-6)
- 1-(3-sulfanylphenyl)ethan-1-one (CAS 3814-19-5)
- Peptide 442 (CAS CATO-CPTD788442)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com