5-Chloro-1-methylpyridin-2(1H)-one CAS 4214-78-2
| CAS No. | 4214-78-2 |
| Molecular Formula | C6H6ClNO |
| Molecular Weight | 143.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-1-methylpyridin-2(1H)-one.
5-Chloro-1-methylpyridin-2(1H)-one (CAS 4214-78-2), molecular formula C6H6ClNO and molecular weight 143.57 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-1-methylpyridin-2(1H)-one (C6H6ClNO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-1-methylpyridin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClNO |
| Molecular Weight | 143.57 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-6-methylpyridin-2-ol (CAS 103997-23-5)
- N-(3-Chloro-phenyl)hydroxylamine (CAS 10468-17-4)
- (5-Chloro pyrazin-2-yl) Methanamine (CAS 1060814-53-0)
- 4-Chloro-3-methylpyridine 1-Oxide (CAS 1073-34-3)
- 2-Chloro-3-hydrazinylpyridine (CAS 117087-45-3)
- 5-Chloro-2-methylpyridin-4(1H)-one (CAS 1196157-19-3)
- 2-Chloro-1-(1H-pyrrol-3-yl)ethanone (CAS 122450-28-6)
- 3-Chloro-2-methylpyridin-4-ol (CAS 1227499-23-1)
Recommended Standards
- 5-Chloro-1-methyl-1H-pyrrole-2-carbaldehyde (CAS 56453-96-4)
- 5-Chloro-2-(hydroxymethyl)pyridine (CAS 209526-98-7)
- 5-Amino-4-chloro-2-methylpyrimidine (CAS 20090-59-9)
- 5-Chloro-2-hydrazinopyridine (CAS 27032-63-9)
- 2,4-Dinitrofluorobenzene-d (CAS 228719-18-4)
- Methyl 2-(2-methoxyphenyl)-5-oxotetrahydrofuran-3-carboxylate (CAS 385376-40-9)
- 1,3-Butadiene, 2,3-dichloro-, polymer with 2-chloro-1,3-butadiene (CAS 25067-95-2)
- 5-(Furan-2-ylmethylene)-2-morpholinothiazol-4(5H)-one (CAS 6975-58-2)
- Methyl 2-amino-5-isobutyloxazole-4-carboxylate (CAS 1072944-88-7)
- Dimethyl [1,1'-biphenyl]-2,2'-dicarboxylate (CAS 5807-64-7)
- 3-(2-Chlorobenzylidene)dihydrofuran-2(3H)-one (CAS 5462-00-0)
- 9-Vinyl-9H-fluorene (CAS 37563-64-7)
- Abiraterone (CAS 154229-19-3)
- Glucagon (1-29) (CAS 16941-32-5)
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