Methyl 3-(chlorosulfonyl)-4-(isopropylsulfonyl)thiophene-2-carboxylate CAS 423768-47-2
| CAS No. | 423768-47-2 |
| Molecular Formula | C9H11ClO6S3 |
| Molecular Weight | 346.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 3-(chlorosulfonyl)-4-(isopropylsulfonyl)thiophene-2-carboxylate (CAS 423768-47-2), molecular formula C9H11ClO6S3 and molecular weight 346.83 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 3-(chlorosulfonyl)-4-(isopropylsulfonyl)thiophene-2-carboxylate (C9H11ClO6S3) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO6S3 |
| Molecular Weight | 346.83 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 3 |
Related Methyl Standards
- Benzyl 4-(2-(chlorosulfonyl)ethyl)piperazine-1-carboxylate (CAS 1196157-58-0)
- 4-(chlorosulfonyl)phenyl 4-methylbenzenesulfonate (CAS 121347-21-5)
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- Ethyl 3-(chlorosulfonyl)-4-(p-tolyl)thiophene-2-carboxylate (CAS 1291486-89-9)
- Benzyl 1-((chlorosulfonyl)methyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate (CAS 2138392-11-5)
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Recommended Standards
- Ketoconazole Impurity 38 (CAS 24123-68-0)
- N-(3-chlorobenzyl)-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-yl)acetamide (CAS 866050-11-5)
- Isopropyl 2-(4-chloro-6-phenylthieno[2,3-d]pyrimidin-2-yl)acetate (CAS 885460-48-0)
- n-(4-Chlorobenzyl)-2-(3-oxo-3,4-dihydro-2h-benzo[b][1,4]thiazin-2-yl)acetamide (CAS 860611-82-1)
- N,N,2,5-Tetramethylbenzenesulfonamide (CAS 28859-96-3)
- (R)-1-(4-Bromo-3-fluorophenyl)-2,2,2-trifluoroethan-1-amine (CAS 1213384-22-5)
- Trans-Cinnamaldehyde (CAS 14371-10-9)
- N-(2-Chloro-4-methylphenyl)-4-fluorobenzamide (CAS 903796-08-7)
- 2,2,2-Trifluoro-1-[4-(trifluoromethyl)-3-indolyl]ethanone (CAS 1448890-70-7)
- 5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile (CAS 1092352-68-5)
- N-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methoxy}-N-[(hydroxyimino)methyl]urea (CAS 400087-73-2)
- N-Methylbenzohydrazide (CAS 1483-24-5)
- 2-(3-Chlorophenyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (CAS 1185101-85-2)
- Exenatide Acetate (CAS 141732-76-5)
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