6-(Difluoromethyl)-5-methylpyrimidin-4(1H)-one CAS 425394-85-0
| CAS No. | 425394-85-0 |
| Molecular Formula | C6H6F2N2O |
| Molecular Weight | 160.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-(Difluoromethyl)-5-methylpyrimidin-4(1H)-one (C6H6F2N2O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
6-(Difluoromethyl)-5-methylpyrimidin-4(1H)-one (CAS 425394-85-0) is a high-purity analytical reference standard with the molecular formula C6H6F2N2O and a molecular weight of 160.12 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 6-(Difluoromethyl)-5-methylpyrimidin-4(1H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H6F2N2O |
| Molecular Weight | 160.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde (CAS 1204298-70-3)
- 1-(Difluoromethyl)-5-methyl-1H-pyrazole-4-carbaldehyde (CAS 1365938-66-4)
- 1-(Difluoromethyl)-3-methyl-1H-pyrazole-4-carbaldehyde (CAS 1365941-43-0)
- 6-(Difluoromethyl)pyrimidine-4,5-diamine (CAS 1706442-59-2)
- 4-(Difluoromethyl)-6-methoxypyrimidine (CAS 1706444-67-8)
- 3-(Difluoromethyl)-6-hydrazinylpyridazine (CAS 1706458-40-3)
- 6-(Difluoromethyl)-2-methylpyrimidin-4-ol (CAS 1713477-40-7)
- (5-(Difluoromethyl)pyrazin-2-yl)methanol (CAS 1784514-72-2)
Recommended Standards
- 5-methyl-2-oxo-1,3-dioxane-5-carboxylic acid (CAS 507471-78-5)
- Dimethyl 2-oxosuccinate (CAS 25007-54-9)
- 5-Methoxy-3,5-dioxopentanoic acid (CAS 78315-99-8)
- Dimethyl oxirane-2,3-dicarboxylate (CAS 56958-97-5)
- Trilostane Impurity 3 (CAS 20051-76-7)
- 2-(Oxetan-3-yl)propanenitrile (CAS 1782884-74-5)
- 3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid (CAS 502607-25-2)
- 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl trichloroacetimidate (CAS 92052-29-4)
- (R)-2-methyl-2-((4-(trifluoromethoxy)phenoxy)methyl)oxirane (CAS 2051583-39-0)
- (S)-7-oxa-2-azaspiro[4.5]Decan-3-one (CAS 2381782-37-0)
- Trans-5-isopropyl-5-(1-methoxyethyl)-2-phenyl-1,3-dioxane (CAS 22644-62-8)
- Ethyl (E)-2-(2-(4-chlorothiazol-5-yl)vinyl)-6-methoxybenzoate (CAS 365542-32-1)
- Co 102862 (CAS 181144-66-1)
- C-Peptide (human) (CAS 33017-11-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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