4-Chloro-6-methylpyrimidine-5-carbonitrile CAS 425395-73-9
| CAS No. | 425395-73-9 |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Chloro-6-methylpyrimidine-5-carbonitrile (CAS 425395-73-9), a certified reference material (molecular formula C6H4ClN3, MW 153.57 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-6-methylpyrimidine-5-carbonitrile (C6H4ClN3) is characterized by a nitrile group, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 4-Chloro-6-methylpyrimidine-5-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 1041864-02-1)
- 2-Chloro-1H-imidazo[4,5-b]pyridine (CAS 104685-82-7)
- 6-Chloro-[1,2,4]triazolo[4,3-a]pyridine (CAS 1048913-70-7)
- 3-chloro-[1,2,3]triazolo[1,5-a]pyridine (CAS 1087206-32-3)
- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine (CAS 1111638-10-8)
- 2-Chloro-5H-pyrrolo[3,2-d]pyrimidine (CAS 1119280-66-8)
- 1-Chloro-4-cyanatobenzene (CAS 1124-59-0)
- 5-Chloro-4-methylpyrimidine-2-carbonitrile (CAS 114969-79-8)
Recommended Standards
- 4-Chloro-6-methylpicolinonitrile (CAS 98141-38-9)
- 4-Chlorobenzo[d]oxazole (CAS 943443-12-7)
- 4-Chloro-5-methylpyrimidine-2-carbonitrile (CAS 955112-51-3)
- 4-Chlorofuro[3,2-c]pyridine, 97% (CAS 31270-80-1)
- 5-Chloro-4-methylbenzene-1,3-diamine (CAS 861519-29-1)
- 4-(4-Methoxyphenyl)-2-methyl-2,4,5,6-tetrahydropyrrolo[2,3-c]pyrazol-3-ol (CAS 1707566-65-1)
- Ethyl 2,3-dihydropyrazolo[5,1-b]oxazole-7-carboxylate (CAS 2073912-30-6)
- 1-Butyl-4-(diethoxymethyl)benzene (CAS 83803-80-9)
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- 2-(1-Aminocyclopropyl)acetic Acid Hydrochloride (CAS 139132-50-6)
- 1-(2-Methoxyethyl)-1h-indole-3-carboxylic acid (CAS 179993-05-6)
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- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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