2-[[(4-Methylphenyl)sulfonyl][3-(trifluoromethyl)phenyl]amino]-N-3-pyridinyl-acetamide CAS 425680-38-2
| CAS No. | 425680-38-2 |
| Molecular Formula | C21H18F3N3O3S |
| Molecular Weight | 449.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-[[(4-Methylphenyl)sulfonyl][3-(trifluoromethyl)phenyl]amino]-N-3-pyridinyl-acetamide is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-[[(4-Methylphenyl)sulfonyl][3-(trifluoromethyl)phenyl]amino]-N-3-pyridinyl-acetamide (CAS 425680-38-2), molecular formula C21H18F3N3O3S and molecular weight 449.45 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 2-[[(4-Methylphenyl)sulfonyl][3-(trifluoromethyl)phenyl]amino]-N-3-pyridinyl-acetamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 449.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-[[(4-Methylphenyl)sulfonyl][3-(trifluoromethyl)phenyl]amino]-N-3-pyridinyl-acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18F3N3O3S |
| Molecular Weight | 449.45 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methylphenyl Standards
- {1-methyl-5-[(4-methylphenyl)sulfanyl]-3-phenyl-1H-pyrazol-4-yl}methyl 4-chlorobenzoate (CAS 318247-41-5)
- 4-[4-(3-Methylphenyl)-5-({[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-4H-1,2,4-triazol-3-yl]morpholine (CAS 920941-31-7)
- 3-(4-Methylphenyl)-1-({4-[5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl}methyl)-1H-1,2,4-triazole-5-thiol (CAS 924235-60-9)
- {4-[(4-methylphenyl)sulfanyl]-3-nitrophenyl}methyl 3-(trifluoromethyl)benzoate (CAS 320424-06-4)
- 2-({5-[2-(4-methylphenyl)quinolin-4-yl]-4-phenyl-4h-1,2,4-triazol-3-yl}sulfanyl)acetic acid (CAS 742094-76-4)
- (3E)-1-[(4-Methylphenyl)methyl]-3-[2-(2,4,6-trichlorophenyl)hydrazin-1-ylidene]-2,3-dihydro-1H-indol-2-one (CAS 320422-09-1)
- Methyl 2-({6-[(4-methylphenyl)sulfanyl]-2-phenylpyrimidin-4-yl}sulfanyl)benzoate (CAS 478067-35-5)
- (2E)-1-[3-(4-Methylphenyl)-2,1-benzoxazol-5-yl]-3-[(3,4,5-trimethoxyphenyl)amino]prop-2-en-1-one (CAS 383147-24-8)
Recommended Standards
- (S)-2-(((Benzyloxy)carbonyl)amino)-3-(4-(((benzyloxy)carbonyl)oxy)phenyl)propanoic acid (CAS 29713-96-0)
- Dihydro Normorphine 3-O-β-D-Glucuronide (CAS 491847-30-4)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,4,5-trimethoxybenzoic acid (CAS 1185303-03-0)
- Dihydro Normorphine 6-O-β-D-Glucuronide (CAS 561323-10-2)
- 2-[(3,4-Dichlorophenyl)sulfanyl]-N,N-bis(propan-2-yl)acetamide (CAS 339097-68-6)
- 3-(2-Methyl-1,3-thiazol-4-yl)benzoic acid (CAS 28077-41-0)
- 2-(2,3-Dimethylphenyl)ethane-1-thiol (CAS 1267865-82-6)
- 7-Iodo-6-methoxy-4-methyl-1H-indazole (CAS 1352397-67-1)
- 5-(4-Fluorophenyl)-2-((4-fluorophenyl)ethynyl)-4-hydroxy-6H-1,3-oxazin-6-one (CAS 1956376-41-2)
- 1-Methyl-2-nitronaphthalene (CAS 63017-87-8)
- 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline,HCl (CAS 495-59-0)
- (Prop-2-en-1-yl)({[3-(trifluoromethyl)phenyl]methyl})amine (CAS 1019484-11-7)
- [5-chloro-2-(morpholin-4-yl)phenyl]methanamine (CAS 1250339-07-1)
- Des-Pro36-37-Tirzepatide (CAS CATO-CPTD788938)
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