Calcium Folinate EP Impurity A CAS 4271-30-1
| CAS No. | 4271-30-1 |
| Molecular Formula | C12H14N2O5 |
| Molecular Weight | 266.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Calcium Folinate EP Impurity A (CAS 4271-30-1) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14N2O5 and a molecular weight of 266.25 g/mol.
The molecular framework of Calcium Folinate EP Impurity A (C12H14N2O5) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14N2O5 |
| Molecular Weight | 266.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Calcium Standards
- Calcium folinate Impurity 12 (CAS 4349-43-3)
- Calcium Folinate EP Impurity B (Mixture of Diastereomers) (CAS 98814-60-9)
- Calcium folinate Impurity 18 (CAS CATO-C4X-22418)
- Calcium folinate Impurity 19 (CAS 77314-00-2)
- Calcium folinate Impurity 11 (CAS CATO-C4X-224111)
- Calcium Folinate Hydrate (CAS 2060570-47-8)
- Calcium Folinate EP Impurity I disodium salt (CAS 133978-76-4)
- Calcium Folinate EP Impurity E calcium salt (CAS CATO-C4X-22417)
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