Dotinurad Impurity 61 CAS 428458-98-4
| CAS No. | 428458-98-4 |
| Molecular Formula | C14H11Cl2NO2 |
| Molecular Weight | 296.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Dotinurad Impurity 61 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Dotinurad Impurity 61 (CAS 428458-98-4, C14H11Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Dotinurad Impurity 61 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 296.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H11Cl2NO2 |
| Molecular Weight | 296.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dotinurad Standards
- Dotinurad Impurity 215 (CAS CATO-C4X-2494215)
- Dotinurad Impurity 203 (CAS CATO-C4X-2494203)
- Dotinurad Impurity 32 (CAS CATO-C4X-249432)
- Dotinurad Impurity 125 (CAS CATO-C4X-2494125)
- Dotinurad Impurity 45 (CAS CATO-C4X-249445)
- Dotinurad Impurity 50 (CAS CATO-C4X-249450)
- Dotinurad Impurity 255 (CAS CATO-C4X-2494255)
- Dotinurad Impurity 90 (CAS CATO-C4X-249490)
Recommended Standards
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- Diclofenac Acid (CAS 15307-86-5)
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- Meclofenamic Acid (CAS 644-62-2)
- Dutasteride Impurity 27 (CAS CATO-C4X-110327)
- Melitracen Impurity 5 (CAS 111-18-2)
- Relebactam Impurity 68 (CAS CATO-C4X-214468)
- Benzyl tetrahydrothiophene-2-carboxylate 1,1-dioxide (CAS 327618-07-5)
- 3,5-Dichloro-2-pyrazinemethanamine (CAS 1211531-66-6)
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- Imidazo[1,2-a]quinoxalin-4-amine (CAS 38346-47-3)
- (E)-3-(5-Fluoropyridin-2-yl)acrylic acid (CAS 917865-78-2)
- Oleacein (CAS 149183-75-5)
- Neuropeptide Y, human (CAS 98264-90-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com