5-Nitroindoline-2-carboxylic acid CAS 428861-44-3
| CAS No. | 428861-44-3 |
| Molecular Formula | C9H8N2O4 |
| Molecular Weight | 208.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 208.17 g/mol gives 5-Nitroindoline-2-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Nitroindoline-2-carboxylic acid (CAS 428861-44-3), molecular formula C9H8N2O4 and molecular weight 208.17 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-Nitroindoline-2-carboxylic acid (C9H8N2O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 208.17 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8N2O4 |
| Molecular Weight | 208.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Nitroindoline Standards
- 5-Nitroindoline-7-carboxylic acid (CAS 133433-66-6)
- 6-Nitroindoline-2-carboxylic acid (CAS 428861-42-1)
- 1-Methyl-5-nitroindoline-2-thione (CAS 156136-71-9)
- 1-Acetyl-6-nitroindoline (CAS 22949-08-2)
- 1-Methyl-6-nitroindoline-2,3-dione (CAS 108726-52-9)
- 1-Methyl-5-nitroindoline-2,3-dione (CAS 3484-32-0)
- 5-methyl-7-nitroindoline-2,3-dione (CAS 90418-79-4)
- Methyl 7-nitroindoline-5-carboxylate (CAS 2167266-06-8)
Recommended Standards
- 5-Nitrobenzofuran-2-carboxamide (CAS 267644-49-5)
- 6-Hydroxy-4-methoxybenzofuran-5-carboxylic acid (CAS 88258-42-8)
- 5-Acetamido-4H-1,2,4-triazole-3-sulfonyl fluoride (CAS 2166700-55-4)
- 5,7-Dimethyl-3-nitropyrazolo[1,5-a]pyrimidin-2(1H)-one (CAS 89977-75-3)
- 3-(2,6-dimethylmorpholin-4-yl)propan-1-amine (CAS 91551-59-6)
- 1,4-Bis(4-bromophenoxy)-2,5-dimethylhexane-2,5-diol (CAS 186498-09-9)
- 2-Chloro-N-(4-ethoxy-2-nitrophenyl)acetamide (CAS 380195-34-6)
- n-(3,4-Dimethylphenyl)-3-(1,3-dioxoisoindolin-2-yl)propanamide (CAS 313267-27-5)
- 3-(2,4-Dichlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (CAS 618098-88-7)
- 7-Methoxyquinoline-3-carboxaldehyde (CAS 72808-91-4)
- (±)-2-Methyl-d3-butyric Acid (CAS 95926-92-4)
- (E)-3-(4-Chlorophenyl)-2-methyl-1-phenyl-2-propen-1-one (CAS 1478988-74-7)
- 1-Oxaspiro[2.7]Decane (CAS 185-88-6)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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