2-(4-Nitrophenyl)-1,3,4-oxadiazole CAS 4291-13-8
| CAS No. | 4291-13-8 |
| Molecular Formula | C8H5N3O3 |
| Molecular Weight | 191.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(4-Nitrophenyl)-1,3,4-oxadiazole (CAS 4291-13-8), molecular formula C8H5N3O3 and molecular weight 191.14 g/mol, is a CATO reference standard with documented purity and traceability.
2-(4-Nitrophenyl)-1,3,4-oxadiazole (C8H5N3O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H5N3O3 |
| Molecular Weight | 191.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
Related Nitrophenyl Standards
- 3-(4-Nitrophenyl)-1,2,4-oxadiazole (CAS 16013-14-2)
- 2-(2-Nitrophenyl)-1,3,4-oxadiazole (CAS 89898-92-0)
- 2-(3-Nitrophenyl)-1,3,4-oxadiazole (CAS 5565-72-0)
- 3-(2-Nitrophenyl)propiolic acid (CAS 530-85-8)
- 3-(3-Nitrophenyl)-1,2,4-oxadiazole (CAS 90049-83-5)
- 3-(3-Nitrophenyl)propiolic acid (CAS 4996-15-0)
- 3-(4-Nitrophenyl)-1,2,5-oxadiazole (CAS 58749-72-7)
- 3-(4-Nitrophenyl)propiolic acid (CAS 2216-24-2)
Recommended Standards
- 2,3-Dioxoindoline-4-carboxylic acid (CAS 41704-95-4)
- 2,3-Dioxoindoline-7-carboxylic acid (CAS 25128-35-2)
- 1,3-Dioxoisoindoline-4-carboxylic acid (CAS 776-22-7)
- 2H-1,3-benzodioxole-5-carbonyl azide (CAS 54022-34-3)
- 4-Chloro-2-[(4-methylphenyl)methanesulfinyl]-5,6,7,8-tetrahydroquinazoline (CAS 477713-76-1)
- 8-Methyl-3,4-dihydro-2h-1,3-benzoxazine-2,4-dione (CAS 24088-78-6)
- (4-Phenylpyrrolidin-3-yl)-carbamic Acid tert-Butyl Ester (CAS 351360-61-7)
- Methyl 4-fluoro-2-(methylamino)benzoate (CAS 97954-38-6)
- 2-CHloro-1-(cyclopropylmethoxy)-4-nitro-benzene (CAS 28583-83-7)
- 6-(Phenylsulfonyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine (CAS 685108-04-7)
- 1H-Thieno[3,2-c]pyrazole-5-carbaldehyde (CAS 1529810-07-8)
- 3-(Tert-butyl)-5-cyanobenzoic acid (CAS 942077-12-5)
- (1S,8R,Z)-8-aminocyclooct-4-ene-1-carboxylic acid hydrochloride (CAS 350015-75-7)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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