Sildenafil Impurity 1 CAS 42926-52-3
| CAS No. | 42926-52-3 |
| Molecular Formula | C9H9ClO2 |
| Molecular Weight | 184.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sildenafil Impurity 1 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sildenafil Impurity 1 (CAS 42926-52-3) is a certified pharmaceutical impurity reference standard with the molecular formula C9H9ClO2 and a molecular weight of 184.62 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Sildenafil Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 184.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClO2 |
| Molecular Weight | 184.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
Related Sildenafil Standards
- Sildenafil Impurity 58 (CAS 383427-88-1)
- Sildenafil Impurity 3 (CAS 139756-02-8)
- Sildenafil Impurity 47 (CAS 247583-78-4)
- Sildenafil Impurity 55 (CAS 92945-27-2)
- Sildenafil Impurity 60 (CAS 503064-95-7)
- Sildenafil Impurity 62 (CAS 116833-23-9)
- Sildenafil Pyrimidine Impurity (CAS 1346600-82-5)
- Sildenafil Impurity 30 (CAS 59259-90-4)
Recommended Standards
- Clopidogrel Impurity 16 (CAS 138228-61-2)
- Tocopherol impurity 39 (CAS 51028-70-7)
- 2-Amino-5-chloro-3-methylbenzamide (CAS 1006619-83-5)
- Bupropion USP Related Compound C (CAS 152943-33-4)
- Cefprozil EP Impurity L (CAS 203007-73-2)
- Crizotinib Impurity 56 (CAS CATO-C4X-102556)
- Methazolamide Impurity 5 (CAS CATO-C4X-34045)
- (1-Cyclohexyl-2,2,2-trifluoroethyl)benzene (CAS 73899-23-7)
- Methyl 4,4,4-trifluoroacetoacetate (CAS 83643-84-9)
- 2-[(4-sulfamoylphenyl)sulfanyl]benzoic acid (CAS 1154996-56-1)
- Meropenem Impurity 36 (CAS CATO-C4X-130936)
- 7-(Trifluoromethyl)quinazolin-2-amine (CAS 190274-20-5)
- (5-(2-Fluorophenyl)-1H-imidazol-2-yl)methanamine (CAS 1156709-37-3)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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