Zopiclone EP Impurity B CAS 43200-81-3
| CAS No. | 43200-81-3 |
| Molecular Formula | C11H7ClN4O2 |
| Molecular Weight | 262.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Zopiclone EP Impurity B (CAS 43200-81-3), a pharmacopoeial impurity reference standard (molecular formula C11H7ClN4O2, MW 262.65 g/mol) used for the identification and quantification of trace impurities in APIs.
Zopiclone EP Impurity B (C11H7ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C11H7ClN4O2 |
| Molecular Weight | 262.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Zopiclone Standards
- Zopiclone Impurity 3 (CAS CATO-C4X-30713)
- Zopiclone Impurity 8 (Mixture of Diastereomers) (CAS CATO-C4X-12388)
- Zopiclone EP Impurity C (CAS 148891-53-6)
- Zopiclone Impurity 18 (CAS 349125-10-6)
- Zopiclone Impurity 15 (CAS 4180-30-7)
- Zopiclone Impurity 2 (CAS 13606-92-3)
- Zopiclone Impurity 16 (CAS 59325-11-0)
- Zopiclone Impurity 17 (CAS 1348046-61-6)
Recommended Standards
- 5-chloranyl-1-[5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidine-2,4-dione 5-chloro-1-[4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione 50-90-8 A828355 (CAS 50-90-8)
- Quazolast (CAS 86048-40-0)
- 1-(6-Chloropyridin-2-yl)-4-(1H-1,2,4-triazol-1-yl)-1H-pyrazol-5-ol (CAS 1007237-30-0)
- 6-Chloro-2-(furan-2-yl)-3-hydroxy-4H-chromen-4-one (CAS 24933-96-8)
- N-Nitroso Dalilesen impurity 36 (CAS CATO-C4X-301036)
- (Z)-Ceftizoxime Open Ring Impurity 2 (CAS CATO-C4X-179330)
- Trelagliptin Impurity 1 (CAS CATO-C4X-10461)
- Methyl 1-(morpholine-4-carboxamido)cyclohexane-1-carboxylate (CAS 1435804-06-0)
- Dapagliflozin Impurity 59 (CAS 14396-73-7)
- 4-Bromo-5-(difluoromethyl)-2-iodo-3-methylpyridine (CAS 1805409-55-5)
- cis-Methyl 4-phenylpyrrolidine-3-carboxylate (CAS 1212214-12-4)
- Lithium hydrogen(3-bromofuran-2-yl)boronate (CAS 2096329-61-0)
- (R)-3,3'-Bis(2-naphthyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2,2'-naphthol (CAS 922711-77-1)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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