Eszopiclone Impurity 25 CAS 43200-88-0
| CAS No. | 43200-88-0 |
| Molecular Formula | C18H11ClN4O4 |
| Molecular Weight | 382.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Eszopiclone Impurity 25 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Eszopiclone Impurity 25 (CAS 43200-88-0) is a certified pharmaceutical impurity reference standard with the molecular formula C18H11ClN4O4 and a molecular weight of 382.76 g/mol.
Eszopiclone Impurity 25 (C18H11ClN4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Eszopiclone Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H11ClN4O4 |
| Molecular Weight | 382.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Eszopiclone Standards
- Eszopiclone (S-Zopiclone) (CAS 138729-47-2)
- Eszopiclone Impurity 21 (CAS CATO-C4X-123821)
- Eszopiclone impurity 26 (CAS 151776-26-0)
- Eszopiclone-d8 (CAS 1093385-24-0)
- Eszopiclone EP Impurity A (CAS 151851-70-6)
- Eszopiclone Impurity 7 (CAS 43200-83-5)
- Eszopiclone Impurity 6 (CAS 1122549-43-2)
- Eszopiclone Impurity 23 (CAS 43200-82-4)
Recommended Standards
- 5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole (CAS 337932-16-8)
- 1,4-Diamino-6-chloro-2-(3-fluorophenoxy)anthracene-9,10-dione (CAS 88605-20-3)
- 4-Chloro-1-methyl-2-phenyl-5-{[3-(trifluoromethyl)phenoxy]methyl}-2,3-dihydro-1H-pyrazol-3-one (CAS 946387-08-2)
- 1,4-Diamino-7-chloro-2-(3-fluorophenoxy)anthracene-9,10-dione (CAS 88605-30-5)
- Rebamipide Impurity 49 (CAS CATO-C4X-152349)
- Linezolid Impurity 9 (CAS 1219708-30-1)
- Nizatidine EP Impurity G (CAS 1193434-63-7)
- 5-Allyl-8-amino-3,3-dimethyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one (CAS 1170001-31-6)
- 5-Oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester (CAS 1417793-01-1)
- Isavuconazole Impurity 154 (CAS CATO-C4X-1236154)
- 2-(6-Hydroxy-4-pyrimidinyl)acetic acid (CAS 1119449-91-0)
- Esmolol Impurity 51 (CAS CATO-C4X-189151)
- Dihydro Tachysterol (CAS 67-96-9)
- Des-Lys20(Side Chain)-Semaglutide (CAS CATO-C4X-2226280)
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