5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole CAS 337932-16-8
| CAS No. | 337932-16-8 |
| Molecular Formula | C18H11ClN4O4 |
| Molecular Weight | 382.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole (CAS 337932-16-8), a certified reference material (molecular formula C18H11ClN4O4, MW 382.76 g/mol) for analytical method development and quality control.
The molecular framework of 5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole (C18H11ClN4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(3-(2-Chlorophenyl)-5-methylisoxazol-4-yl)-3-(4-nitrophenyl)-1,2,4-oxadiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H11ClN4O4 |
| Molecular Weight | 382.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chlorophenyl Standards
- N-(4-chlorophenyl)-7-fluoro-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 338778-19-1)
- 2-(3-(4-Chlorophenyl)-5,9-dimethyl-7-oxo-7H-furo[3,2-g]chromen-6-yl)acetic acid (CAS 664366-16-9)
- 2-(4-Chlorophenyl)-N-(3-(trifluoromethyl)phenyl)thiazole-4-carboxamide (CAS 303998-34-7)
- 3-(2-Chlorophenyl)-4-((2-(trifluoromethyl)benzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-06-7)
- 3-(2-Chlorophenyl)-4-((4-(trifluoromethyl)benzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-47-6)
- 3-(3-(4-Chlorophenyl)-5-methyl-7-oxo-7H-furo[3,2-g]chromen-6-yl)propanoic acid (CAS 777857-52-0)
- 3-(3-Chlorophenyl)-4-((2-(trifluoromethyl)benzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478254-86-3)
- 3-(3-Chlorophenyl)-4-((4-(trifluoromethyl)benzylidene)amino)-1H-1,2,4-triazole-5(4H)-thione (CAS 478255-35-5)
Recommended Standards
- 4-Chloro-1-methyl-2-phenyl-5-{[3-(trifluoromethyl)phenoxy]methyl}-2,3-dihydro-1H-pyrazol-3-one (CAS 946387-08-2)
- Eszopiclone Impurity 25 (CAS 43200-88-0)
- (5-((4-Fluorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl 2-chloroacetate (CAS 318469-26-0)
- 1,4-Diamino-6-chloro-2-(3-fluorophenoxy)anthracene-9,10-dione (CAS 88605-20-3)
- (2E)-2-[(2E)-3-Phenylprop-2-en-1-ylidene]-1-azabicyclo[2.2.2]octan-3-one (CAS 478261-95-9)
- 1-benzyl-3,4-dimethyl-1h-phosphole 39099-23-5 AR-1C1743 (CAS 39099-23-5)
- prop-1-en-2-ylcyclopropane (CAS 4663-22-3)
- (3-Chloro-4-fluorophenyl)(2-chloro-6-fluorobenzyl)sulfane (CAS 1443303-73-8)
- Methyl 2-amino-4-(trifluoromethoxy)benzoate (CAS 158580-96-2)
- N-(3-(6-Oxo-3-phenylpyridazin-1(6H)-yl)propyl)-2-phenylethane-1-sulfonamide (CAS 1021091-25-7)
- Ethyl 3-hydroxy-5-methylhexanoate (CAS 40309-43-1)
- (S)-N-((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide (CAS 1510-07-2)
- 3-Nitropropionic Acid (CAS 504-88-1)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
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