5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one CAS 4354-76-1
| CAS No. | 4354-76-1 |
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (CAS 4354-76-1), molecular formula C22H22O8 and molecular weight 414.41 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one (C22H22O8) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22O8 |
| Molecular Weight | 414.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
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Recommended Standards
- 2-Amino-6-benzyl-7-methyl-4-(4-nitrophenyl)-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile (CAS 265315-77-3)
- Picropodophyllotoxin (CAS 477-47-4/17434-18-3)
- 2-Amino-6-benzyl-7-methyl-4-(3-nitrophenyl)-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile (CAS 265315-71-7)
- (-)-Epipodophyllotoxin (CAS 4375-07-9)
- 2-Propyl-4,5-dihydrothiazole (CAS 23185-09-3)
- 1,2,3-thiadiazole-4-carboxamide (CAS 4100-20-3)
- 5-(4-Chlorophenyl)oxazolidin-2-one (CAS 69776-87-0)
- Tert-butyl (2-(5-methoxy-1H-indol-3-yl)ethyl)carbamate (CAS 380358-27-0)
- 7-Bromo-2-(tert-butyl)quinazolin-4(1H)-one (CAS 1354455-86-9)
- 3-(4-Chloro-2-fluoro-5-methoxyphenyl)-5-(methylthio)-1H-pyrazole (CAS 141577-01-7)
- Selexipag Impurity 17 (CAS 475086-28-3)
- (Z)-Cefotaxime Impurity 19 (CAS 98368-23-1)
- Azlocillin Open-Ring Impurity (CAS 96688-41-4)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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