436088-41-4 5-tert-Butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid 5-tert-butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazol[1,5-a]pyrimidine-2-carboxylic acid 436088- CAS 436088-41-4
| CAS No. | 436088-41-4 |
| Molecular Formula | C12H16F3N3O2 |
| Molecular Weight | 291.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
436088-41-4 5-tert-Butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid 5-tert-butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazol[1,5-a]pyrimidine-2-carboxylic acid 436088- (CAS 436088-41-4) is a high-purity analytical reference standard with the molecular formula C12H16F3N3O2 and a molecular weight of 291.27 g/mol.
The molecular framework of 436088-41-4 5-tert-Butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid 5-tert-butyl-7-trifluoromethyl-4,5,6,7-tetrahydro-pyrazol[1,5-a]pyrimidine-2-carboxylic acid 436088- (C12H16F3N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16F3N3O2 |
| Molecular Weight | 291.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
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- tert-Butyl 3-(trifluoromethyl)-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate (CAS 733757-89-6)
- Levofloxacin Impurity 18 (CAS 431058-46-7)
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- Olaparib Impurity 128 (CAS CATO-C4X-1135128)
- methyl 5-chloro-2-methyl-1H-indole-3-carboxylate (CAS 762288-06-2)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-(((4-chlorobenzyl)thio)methyl)-4-ethyl-4H-1,2,4-triazole (CAS 344273-89-8)
- 4-(Pyrimidin-2-yl)morpholine (CAS 57356-66-8)
- 1-(5-Hydroxycyclopent-1-en-1-yl)ethanone (CAS 70433-48-6)
- Pyrazine-2-carboximidamide hydrochloride(1:x) (CAS 328042-01-9)
- MLCK inhibitor peptide 18 (CAS 224579-74-2)
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