Levofloxacin Impurity 18 CAS 431058-46-7
| CAS No. | 431058-46-7 |
| Molecular Formula | C15H14FNO4 |
| Molecular Weight | 291.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin Impurity 18.
As a process- or degradation-related impurity, Levofloxacin Impurity 18 (CAS 431058-46-7, C15H14FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Levofloxacin Impurity 18 (C15H14FNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 291.27 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14FNO4 |
| Molecular Weight | 291.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Levofloxacin Standards
- Levofloxacin impurity 90 (CAS CATO-C4X-137190)
- Levofloxacin Impurity 03 (CAS 1213269-49-8)
- Levofloxacin Impurity 96 (CAS CATO-C4X-137196)
- Levofloxacin Impurity 56 (CAS 82419-44-1)
- Levofloxacin Impurity 57 (CAS 95849-23-3)
- Levofloxacin Impurity 12 (CAS 1798887-79-2)
- Levofloxacin Impurity 51 (CAS 1026952-91-9)
- Levofloxacin EP Impurity F (CAS 100986-89-8)
Recommended Standards
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- Enrofloxacin Impurity 13 (CAS 2388490-12-6)
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