4-Fluoro-N,N-diphenylaniline CAS 437-25-2
| CAS No. | 437-25-2 |
| Molecular Formula | C18H14FN |
| Molecular Weight | 263.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Fluoro-N,N-diphenylaniline (CAS 437-25-2) is a high-purity analytical reference standard with the molecular formula C18H14FN and a molecular weight of 263.31 g/mol.
The molecular framework of 4-Fluoro-N,N-diphenylaniline (C18H14FN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Fluoro-N,N-diphenylaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14FN |
| Molecular Weight | 263.31 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 4-Aminophenyl 4-methylbenzenesulfonate (CAS 3899-93-2)
- 4-HYdroxy-n-(4-methylphenyl)benzene-1-sulfonamide (CAS 76410-74-7)
- 4-(O-tolyloxy)benzenesulfonamide (CAS 342612-91-3)
- 4-Methoxy-3-((2-methylthiazol-4-yl)methoxy)benzaldehyde (CAS 923819-76-5)
- 2-(3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid (CAS 449778-74-9)
- tert-Butyl 3-(chloromethyl)-4-methylphenylcarbamate (CAS 1211511-27-1)
- 1-(Benzyloxy)-4-ethoxybenzene (CAS 69697-44-5)
- 1-Oxoisoindoline-2-carbonyl chloride (CAS 74572-58-0)
- Methyl 5-(2-chlorophenyl)nicotinate (CAS 893734-64-0)
- Ethyl 2-[2-(aminocarbonyl)hydrazono]-3-[(4-chlorophenyl)sulfanyl]propanoate (CAS 886361-57-5)
- Tofacitinib Nitroso Impurity 188 (CAS CATO-C4X-1079188)
- Ethyl 3-(4-(chloromethyl)phenyl)propanoate (CAS 107859-99-4)
- 2-Amino-1-(5-bromothiophen-2-yl)propan-1-one (CAS 1216001-89-6)
- Semaglutide impurity 275 (CAS CATO-C4X-2226275)
Why CATO?
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