5-Chloro-2-hydroxy-3-methylbenzoic acid CAS 4386-40-7
| CAS No. | 4386-40-7 |
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-2-hydroxy-3-methylbenzoic acid (CAS 4386-40-7), molecular formula C8H7ClO3 and molecular weight 186.59 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-2-hydroxy-3-methylbenzoic acid (C8H7ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-2-(hydroxymethyl)benzoic acid (CAS 100448-59-7)
- Methyl 2-Chloro-4-hydroxybenzoate (CAS 104253-44-3)
- 3-Chloro-2,4-dihydroxy-6-methylbenzaldehyde (CAS 106325-72-8)
- 2-Chloro-4-(hydroxymethyl)benzoic acid (CAS 1071989-48-4)
- Methyl 2-chloro-3-hydroxybenzoate (CAS 1125632-11-2)
- 2-Chloro-6-hydroxy-4-methoxybenzaldehyde (CAS 116475-68-4)
- 2-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-13-6)
- 4-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-15-8)
Recommended Standards
- 5-Chloro-2-(hydroxymethyl)benzoic acid (CAS 627909-53-9)
- 5-Chloro-2-hydroxy-4-methoxybenzaldehyde (CAS 89938-56-7)
- 4-Chlorophenylglyoxal hydrate (CAS 4996-21-8)
- 5-Chloro-2-hydroxy-4-methylbenzoic acid (CAS 35458-35-6)
- Benzyl (tetrahydro-2H-pyran-3-yl)carbamate (CAS 1864058-16-1)
- CAS 62081-18-9 (CAS 62081-18-9)
- 2-Fluoro-4-phenylphenol (CAS 84376-21-6)
- 5-(((2-Oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxy)methyl)furan-2-carboxylic acid (CAS 953891-31-1)
- 1-(Pyrimidin-2-yl)pentan-1-amine (CAS 1250417-03-8)
- 2-Pentylquinoline-4,6-diamine (CAS 423184-78-5)
- 2-(Isoquinolin-7-yl)ethanamine (CAS 1158755-12-4)
- 1-(Isothiazol-3-yl)ethan-1-one (CAS 88511-35-7)
- Amitriptyline Hydrochloride (CAS 549-18-8)
- D-[Ser]8-Semaglutide (CAS CATO-CPTD788632)
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