3-Chloro-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyridin-2-amine CAS 439111-22-5
| CAS No. | 439111-22-5 |
| Molecular Formula | C16H13ClF3N3 |
| Molecular Weight | 339.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Chloro-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyridin-2-amine (CAS 439111-22-5) is a high-purity analytical reference standard with the molecular formula C16H13ClF3N3 and a molecular weight of 339.74 g/mol.
The molecular framework of 3-Chloro-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyridin-2-amine (C16H13ClF3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures 3-Chloro-N-[2-(1H-indol-3-yl)ethyl]-5-(trifluoromethyl)pyridin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H13ClF3N3 |
| Molecular Weight | 339.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 2-(6-Chloropyridin-3-yl)-1-isopropyl-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 400074-14-8)
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- Mabuterol Impurity 7 (CAS CATO-C4X-14547)
- 1-(2-Chlorophenyl)-4-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-5-amine (CAS 892766-42-6)
- (S)-3-(1-Amino-2,2,2-trifluoroethyl)aniline (CAS 1213520-51-4)
- 2,3-Dihydroxy-4-methylbenzoic acid (CAS 3929-89-3)
- (7S,9S)-9-Acetyl-7-[(2R,3R,4R,5S,6S)-3-Fluoro-4,5-Dihydroxy-6-Methyloxan-2-Yl]Oxy-6,9,11-Trihydroxy-4-Methoxy-8,10-Dihydro-7H-Tetracene-5,12-Dione (CAS 103946-11-8)
- 2-(1-Benzylpiperidin-4-yl)-2-propanol (CAS 299428-04-9)
- Methyldiphenylphosphine oxide (CAS 2129-89-7)
- (2S)-2-amino-3-methyl-N-(2-(trifluoromethyl)phenyl)pentanamide hydrochloride (CAS 1266684-36-9)
- Tert-butyl (e)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylate (CAS 1202645-17-7)
- 4-Amino-6-chloroquinoline-3-carboxylic acid (CAS 933740-79-5)
- N-{5-azaspiro[3.5]nonan-8-yl}pentanamide hydrochloride (CAS 1909306-18-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com